Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 7/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18210065 | 0.86 | RORC (0.40) | EPHX2RORCNR1H2JAK1USP2 | |
| SCHEMBL2217516 | 0.86 | RORC (0.40) | EPHX2RORCNR1H2JAK1USP2 | |
| SCHEMBL31603740 | 0.84 | EPHX2 (0.39) | EPHX2RORCNR1H2JAK1PDE4B | |
| SCHEMBL21811733 | 0.81 | MMP2 (0.30) | — | |
| SCHEMBL24087434 | 0.81 | NR1H2 (0.41) | EPHX2RORCNR1H2JAK1USP2 | |
| SCHEMBL27171881 | 0.81 | NR1H2 (0.41) | EPHX2RORCNR1H2JAK1USP2 | |
| SCHEMBL24695414 | 0.81 | NR1H2 (0.41) | EPHX2RORCNR1H2JAK1USP2 | |
| SCHEMBL2278303 | 0.81 | USP2 (0.43) | EPHX2RORCNR1H2USP2SMN1; SMN2 | |
| SCHEMBL12991777 | 0.78 | HSD11B1 (0.37) | EPHX2RORCNR1H2EPHX1HSD11B1 | |
| SCHEMBL23807876 | 0.77 | EPHX2 (0.42) | EPHX2RORCNR1H2USP2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112739420-A | Phenoxy-pyridyl-pyrimidine compounds and methods of use | 基因泰克公司 | 2021-04-30 | — | — | CN | disclosed |
| WO-2020056089-A1 | PHENOXY-PYRIDYL-PYRIMIDINE COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2020-03-19 | — | — | WO | disclosed |