SCHEMBL21909

SCHEMBL21909

O=C(CCCCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21)NC=CCc1cn([C@H]2C[C@H](O)[C@@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)[nH]c1=O

nearest known ligand 0.48

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
PLCD1 P51178 1/20 0.48
F2 P00734 2/20 0.44
FGF1 P05230 1/20 0.41
FGF2 P09038 1/20 0.41
VEGFA P15692 1/20 0.41
HPSE Q9Y251 1/20 0.41
HLCS P50747 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
PRSS1 P07477 1/20 0.39
PRSS2 P07478 1/20 0.39
PRSS3 P35030 1/20 0.39
TPSAB1 Q15661 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1926090 0.99 PLCD1 (0.48) PLCD1F2FGF1FGF2VEGFA
SCHEMBL5685965 0.96 F2 (0.47) PLCD1F2HLCS
SCHEMBL7532610 0.92 PLCD1 (0.48) PLCD1F2FGF1FGF2VEGFA
SCHEMBL7644975 0.92 PLCD1 (0.43) PLCD1F2FGF1FGF2VEGFA
SCHEMBL20129499 0.88 PLCD1 (0.49) PLCD1F2FGF1FGF2VEGFA
SCHEMBL29426309 0.87 PLCD1 (0.49) PLCD1F2FGF1FGF2VEGFA
SCHEMBL9004512 0.87 F2 (0.43) PLCD1F2FGF1FGF2VEGFA
SCHEMBL29627228 0.86 PLCD1 (0.47) PLCD1F2FGF1FGF2VEGFA
Biotin SCHEMBL9489122 0.86 F2 (0.48) F2HLCSTDP1
SCHEMBL6534840 0.84 TK1 (0.46) F2FGF1FGF2VEGFAHPSE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 423 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025054337-A1 CO-TARGETING NCOA3 AND PD-1 FOR CANCER THERAPY SUTTER BAY HOSPITALS (US) 2025-03-13 WO disclosed
WO-2025039033-A1 METHODS AND REAGENTS FOR DIAGNOSIS AND/OR PROGNOSIS OF TRAUMATIC BRAIN INJURY GLIA DIAGNOSTICS PTY LTD (AU) 2025-02-27 WO disclosed
EP-3274008-B1 DETECTION OF BRAIN INJURY THE UNIV OF MONTANA (US) 2024-12-04 EP disclosed
US-20220290159-A1 miRNAS FOR REDUCING VENTRICLE ENLARGEMENT St. Jude Children's Research Hpspital, Inc. (US) 2022-09-15 US disclosed
CN-107427614-B Detection of brain injury 蒙大拿大学 2021-10-15 CN disclosed
US-11142796-B2 MIR-18B for use as a marker of cancer progression and target for therapies to treat cancer SUTTER BAY HOSPITALS (US) 2021-10-12 US disclosed
EP-2898098-B1 MIR-18B FOR USE AS A MARKER OF CANCER PROGRESSION AND TARGET FOR THERAPIES TO TREAT CANCER SUTTER WEST BAY HOSPITALS (US) 2021-05-05 EP disclosed
WO-2021016425-A1 MIRNAS FOR REDUCING VENTRICLE ENLARGEMENT ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. (US) 2021-01-28 WO disclosed
US-10815529-B2 Detection of traumatic brain injury THE UNIVERSITY OF MONTANA (US) 2020-10-27 US disclosed
US-20190352716-A1 DETECTION OF TRAUMATIC BRAIN INJURY THE UNIVERSITY OF MONTANA (US) 2019-11-21 US disclosed
US-20020177138-A1 Methods for the indentification of textual and physical structured query fragments for the analysis of textual and biopolymer information THE UNITED STATES OF AMERICA , REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES 2002-11-28 US disclosed
EP-1066411-A1 METHODS FOR CANCER PROGNOSIS AND SCREENING ANTIPROLIFERATIVE AGENTS Temple University of the Commonwealth System of Higher Education (US) 2001-01-10 EP disclosed
WO-1999050455-A1 METHODS FOR CANCER PROGNOSIS AND SCREENING ANTIPROLIFERATIVE AGENTS TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 1999-10-07 WO disclosed
WO-1999039200-A1 MOLECULAR MARKERS FOR DIAGNOSING HEPATOCELLULAR CARCINOMA THOMAS JEFFERSON UNIVERSITY (US) 1999-08-05 WO disclosed
EP-0906448-A1 METHODS FOR THE DIAGNOSIS AND PROGNOSIS OF CANCER THOMAS JEFFERSON UNIVERSITY (US) 1999-04-07 EP disclosed
US-5840506-A QUANTIFYING THE EXPRESSION OF TUMOR SUPPRESSOR GENE PRB2/P130 BY MEASURING MESSENGER RNA OR PROTEIN; IMMUNOHISTOCHEMICAL STAINING OF TISSUE BIOPSIES THOMAS JEFFERSON UNIVERSITY (US) 1998-11-24 US disclosed
WO-1997038125-A1 METHODS FOR THE DIAGNOSIS AND PROGNOSIS OF CANCER THOMAS JEFFERSON UNIVERSITY (US) 1997-10-16 WO disclosed
US-5427916-A Measuring gene expression(through determinations of genetic transcription) of growth-controlling oncogenes, then comparing values obtained before and after administering antitumor agents TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 1995-06-27 US disclosed
EP-0341904-B1 Method for predicting the effectiveness of antineoplastic therapy in individual patients UNIV TEMPLE (US) 1995-03-29 EP disclosed
EP-0341904-A2 Method for predicting the effectiveness of antineoplastic therapy in individual patients Temple University of the Commonwealth System of Higher Education (US) 1989-11-15 EP disclosed