Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 1/20 | 0.45 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CKS1B | P61024 | 1/20 | 0.39 |
| ▸ | SKP1 | P63208 | 1/20 | 0.39 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18942729 | 0.90 | AKT1 (0.49) | PDCD1CD274SIGMAR1HDAC3HDAC1 | |
| SCHEMBL20574374 | 0.86 | POLB (0.48) | POLBLMNATDP1MEN1KMT2A | |
| SCHEMBL18942615 | 0.82 | POLB (0.46) | POLBLMNATDP1MEN1KMT2A | |
| SCHEMBL18942757 | 0.81 | CKS1B (0.46) | PDCD1CD274SIGMAR1HDAC3HDAC1 | |
| SCHEMBL5396576 | 0.78 | HDAC3 (0.52) | SIGMAR1HDAC3HDAC1HDAC8HDAC6 | |
| SCHEMBL14846284 | 0.77 | POLB (0.50) | MALT1POLBLMNATDP1MEN1 | |
| SCHEMBL17527969 | 0.76 | AKT1 (0.48) | SIGMAR1MALT1AKT1TDP1DRD2 | |
| SCHEMBL31490537 | 0.76 | CA1 (0.38) | SIGMAR1MALT1LMNATDP1MEN1 | |
| SCHEMBL24813932 | 0.75 | KMT2A (0.46) | SIGMAR1MALT1POLBLMNATDP1 | |
| SCHEMBL18942621 | 0.75 | KMT2A (0.41) | POLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110914240-B | Norbornenone compounds releasing carbon monoxide | 奥塔哥创新有限公司 | 2024-02-20 | — | — | CN | disclosed |
| EP-3383846-B1 | CARBON MONOXIDE RELEASING NORBORNENONE COMPOUNDS | OTAGO INNOVATION LTD (NZ) | 2022-06-22 | — | — | EP | disclosed |
| US-11072584-B2 | Carbon monoxide releasing norbornenone compounds | OTAGO INNOVATION LIMITED (NZ) | 2021-07-27 | — | — | US | disclosed |
| US-20200109115-A1 | CARBON MONOXIDE RELEASING NORBORNENONE COMPOUNDS | AUCKLAND UNISERVICES LIMITED (NZ) | 2020-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200109115-A1 | CARBON MONOXIDE RELEASING NORBORNENONE COMPOUNDS | HMOX1, MB, NOS2 | PDCD1 374/4885CD274 294/4885SIGMAR1 144/4885 |
| US-11072584-B2 | Carbon monoxide releasing norbornenone compounds | HMOX1, MB, NOS2 | PDCD1 374/4885CD274 294/4885SIGMAR1 144/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.