Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 2/20 | 0.35 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10332075 | 0.83 | SMN1; SMN2 (0.39) | LMNASMN1; SMN2CYP2C9TSHRAPEX1 | |
| SCHEMBL19584225 | 0.83 | LMNA (0.39) | LMNASMN1; SMN2CYP2C9TSHRAPEX1 | |
| SCHEMBL16816819 | 0.81 | LOX (0.41) | LMNASMN1; SMN2CYP2C9TSHRAPEX1 | |
| SCHEMBL3396077 | 0.81 | LMNA (0.38) | LMNASMN1; SMN2CYP2C9TSHRAPEX1 | |
| SCHEMBL366394 | 0.81 | NPC1 (0.43) | LMNASMN1; SMN2CYP2C9TSHRAPEX1 | |
| SCHEMBL24086637 | 0.79 | SMN1; SMN2 (0.36) | LMNASMN1; SMN2CYP2C9TSHRAPEX1 | |
| SCHEMBL14653151 | 0.79 | POLB (0.37) | LMNASMN1; SMN2CYP2C9TSHRAPEX1 | |
| SCHEMBL5942205 | 0.75 | SMN1; SMN2 (0.41) | LMNASMN1; SMN2CYP2C9TSHRAPEX1 | |
| SCHEMBL15036520 | 0.74 | ALDH1A1 (0.37) | TDP1MAPT | |
| SCHEMBL7055864 | 0.74 | SMN1; SMN2 (0.64) | LMNASMN1; SMN2CYP2C9TSHRAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020064009-A1 | SUBSTITUTED PYRAZOLE FUSED RING DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 北京志健金瑞生物医药科技有限公司 | 2020-04-02 | — | — | WO | disclosed |