Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | PDE5A | O76074 | 2/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.33 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | PNMT | P11086 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17253975 | 0.81 | PIK3CA (0.38) | PDE10A | |
| SCHEMBL17254178 | 0.81 | ABCB11 (0.33) | HCRTR1HCRTR2RORCCPB2PDE10A | |
| SCHEMBL19584225 | 0.80 | LMNA (0.39) | POLBLMNACYP2C9TSHRAPEX1 | |
| SCHEMBL10332075 | 0.80 | SMN1; SMN2 (0.39) | POLBLMNACYP2C9TSHRAPEX1 | |
| SCHEMBL17069188 | 0.80 | AAK1 (0.39) | SMN1; SMN2SCN9A | |
| SCHEMBL16816819 | 0.79 | LOX (0.41) | LMNACYP2C9TSHRAPEX1SMN1; SMN2 | |
| SCHEMBL3396077 | 0.79 | LMNA (0.38) | LMNACYP2C9TSHRAPEX1SMN1; SMN2 | |
| SCHEMBL366394 | 0.79 | NPC1 (0.43) | POLBLMNACYP2C9TSHRAPEX1 | |
| SCHEMBL21909730 | 0.79 | LMNA (0.38) | POLBLMNACYP2C9TSHRAPEX1 | |
| SCHEMBL13018929 | 0.78 | ALDH1A1 (0.45) | SMN1; SMN2CPB2PNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9695166-B2 | Pyrazolopyridine pyrazolopyrimidine and related compounds | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2017-07-04 | — | — | US | disclosed |
| WO-2015171527-A1 | PYRAZOLOPYRIDINE PYRAZOLOPYRIMIDINE AND RELATED COMPOUNDS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2015-11-12 | — | — | WO | disclosed |
| WO-2013010382-A1 | HETEROCYCLIC SUBSTITUTED PYRIMIDINE COMPOUND | 山东亨利医药科技有限责任公司 (CN) | 2013-01-24 | — | — | WO | disclosed |