SCHEMBL21914836

SCHEMBL21914836

O=C(Nc1cccc2ccccc12)c1cc(C(=O)Nc2cccc3ccccc23)cc(C(=O)Nc2cccc3ccccc23)c1

nearest known ligand 0.80

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 5/20 0.80
RAB9A P51151 5/20 0.80
CYP1A2 P05177 2/20 0.80
CYP3A4 P08684 2/20 0.80
CYP2D6 P10635 2/20 0.80
CYP2C19 P33261 2/20 0.80
CYP2C9 P11712 1/20 0.80
ALOX5 P09917 1/20 0.70
KMT2A Q03164 4/20 0.65
KDM4E B2RXH2 3/20 0.65
GAA P10253 2/20 0.65
HSD17B10 Q99714 1/20 0.61
LMNA P02545 1/20 0.59
PTGES O14684 1/20 0.58
CHRNB2 P17787 1/20 0.58
CHRNB4 P30926 1/20 0.58
CHRNA3 P32297 1/20 0.58
CHRNA4 P43681 1/20 0.58
MAPT P10636 3/20 0.57
EGFR P00533 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28670323 0.91 NPC1 (0.73) NPC1RAB9ACYP1A2CYP3A4CYP2D6
SCHEMBL4642544 0.89 NPC1 (1.00) NPC1RAB9ACYP1A2CYP3A4CYP2D6
SCHEMBL30184438 0.89 NPC1 (1.00) NPC1RAB9ACYP1A2CYP3A4CYP2D6
SCHEMBL27561288 0.89 RAB9A (0.79) NPC1RAB9ACYP1A2CYP3A4CYP2D6
SCHEMBL27982176 0.87 RAB9A (0.66) NPC1RAB9ACYP1A2CYP3A4CYP2D6
SCHEMBL26885232 0.86 NPC1 (0.81) NPC1RAB9ACYP1A2CYP3A4CYP2D6
SCHEMBL7539037 0.84 NPC1 (0.78) NPC1RAB9ACYP1A2CYP3A4CYP2D6
SCHEMBL3659724 0.84 RAB9A (0.84) NPC1RAB9ACYP1A2CYP3A4CYP2D6
SCHEMBL1196106 0.84 RAB9A (0.71) NPC1RAB9ACYP1A2CYP3A4CYP2D6
SCHEMBL18773847 0.84 KMT2A (0.77) NPC1RAB9ACYP1A2CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11656384-B2 Composition, film, lens, solid state imaging element, and compounds FUJIFILM CORPORATION (JP) 2023-05-23 US disclosed
US-20200116896-A1 COMPOSITION, FILM, LENS, SOLID STATE IMAGING ELEMENT, AND COMPOUNDS FUJIFILM CORPORATION (JP) 2020-04-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11656384-B2 Composition, film, lens, solid state imaging element, and compounds UACA, F12, ERGIC1 NPC1 494/4885RAB9A 2214/4885CYP1A2 3168/4885
US-20200116896-A1 COMPOSITION, FILM, LENS, SOLID STATE IMAGING ELEMENT, AND COMPOUNDS UACA, F12, ERGIC1 NPC1 494/4885RAB9A 2214/4885CYP1A2 3168/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.