Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | TACR1 | P25103 | 5/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | MC4R | P32245 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20594570 | 1.00 | SIGMAR1 (0.49) | SIGMAR1SMN1; SMN2TACR1CHRM3CHRM2 | |
| SCHEMBL20523462 | 0.87 | TACR1 (0.50) | SIGMAR1SMN1; SMN2TACR1CHRM3CHRM2 | |
| SCHEMBL4296370 | 0.86 | GAA (0.47) | SIGMAR1SMN1; SMN2DRD2ALDH1A1 | |
| SCHEMBL21852698 | 0.82 | SIGMAR1 (0.49) | SIGMAR1SMN1; SMN2TACR1DRD2DRD4 | |
| SCHEMBL20594812 | 0.82 | SIGMAR1 (0.49) | SIGMAR1SMN1; SMN2TACR1DRD2DRD4 | |
| SCHEMBL23415876 | 0.74 | FUCA1 (0.42) | — | |
| SCHEMBL23415856 | 0.74 | FUCA1 (0.42) | — | |
| SCHEMBL20522902 | 0.74 | SIGMAR1 (0.46) | SIGMAR1SMN1; SMN2TACR1DRD2DRD4 | |
| SCHEMBL6959368 | 0.74 | FUCA1 (0.47) | SIGMAR1SMN1; SMN2TACR1DRD2DRD4 | |
| SCHEMBL23225374 | 0.74 | ALDH1A1 (0.58) | SIGMAR1SMN1; SMN2CHRM3CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11034698-B2 | Pyrazolo[ 1,5a]pyrimidine derivatives as IRAK4 modulators | GENENTECH, INC. (US) | 2021-06-15 | — | — | US | disclosed |
| US-20200123166-A1 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | GENENTECH, INC. (US) | 2020-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11034698-B2 | Pyrazolo[ 1,5a]pyrimidine derivatives as IRAK4 modulators | IRAK4, IRAK1, IRAK2 | SIGMAR1 2713/4885SMN1; SMN2 2964/4885TACR1 4713/4885 |
| US-20200123166-A1 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | IRAK4, IRAK1, IRAK2 | SIGMAR1 2713/4885SMN1; SMN2 2964/4885TACR1 4713/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.