Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.46 |
| ▸ | PTGIR | P43119 | 1/20 | 0.41 |
| ▸ | CXCR3 | P49682 | 9/20 | 0.40 |
| ▸ | STAT1 | P42224 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.35 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2194087 | 0.86 | KMT2A (0.52) | KMT2AMEN1TP53PABPC1CXCR3 | |
| SCHEMBL2194340 | 0.82 | MEN1 (0.46) | KMT2AMEN1TP53PABPC1PTGIR | |
| SCHEMBL2192568 | 0.80 | TP53 (0.42) | KMT2AMEN1TP53PABPC1CXCR3 | |
| SCHEMBL2218436 | 0.77 | MEN1 (0.44) | KMT2AMEN1TP53PABPC1CXCR3 | |
| SCHEMBL15157728 | 0.77 | ALDH1A1 (0.48) | KMT2AMEN1TP53PABPC1CXCR3 | |
| SCHEMBL2220958 | 0.77 | KMT2A (0.50) | KMT2AMEN1TP53PABPC1CXCR3 | |
| SCHEMBL2222060 | 0.74 | TP53 (0.47) | KMT2AMEN1TP53PABPC1CXCR3 | |
| SCHEMBL2217138 | 0.74 | ALDH1A1 (0.45) | KMT2AMEN1TP53PABPC1CXCR3 | |
| SCHEMBL2193330 | 0.72 | KMT2A (0.43) | KMT2AMEN1TP53PABPC1CXCR3 | |
| SCHEMBL3585422 | 0.72 | MEN1 (0.61) | KMT2AMEN1TP53PABPC1CXCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519522-A2 | SUBSTITUTED IMIDAZOPYRIDINYL-AMINOPYRIDINE COMPOUNDS | ArQule, Inc. (US) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011082270-A2 | SUBSTITUTED IMIDAZOPYRIDINYL-AMINOPYRIDINE COMPOUNDS | ARQULE. INC. (US) | 2011-07-07 | — | — | WO | disclosed |