Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | CXCR3 | P49682 | 3/20 | 0.38 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.38 |
| ▸ | PTGIR | P43119 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2194087 | 0.93 | KMT2A (0.52) | MEN1TP53PABPC1KMT2AALDH1A1 | |
| SCHEMBL15157728 | 0.83 | ALDH1A1 (0.48) | MEN1TP53PABPC1KMT2AALDH1A1 | |
| SCHEMBL2218436 | 0.83 | MEN1 (0.44) | MEN1TP53PABPC1KMT2AALDH1A1 | |
| SCHEMBL2192292 | 0.82 | KMT2A (0.46) | MEN1TP53PABPC1KMT2ACXCR3 | |
| SCHEMBL2220958 | 0.81 | KMT2A (0.50) | MEN1TP53PABPC1KMT2AALDH1A1 | |
| SCHEMBL2217138 | 0.80 | ALDH1A1 (0.45) | MEN1TP53PABPC1KMT2AALDH1A1 | |
| SCHEMBL2192568 | 0.79 | TP53 (0.42) | MEN1TP53PABPC1KMT2AALDH1A1 | |
| SCHEMBL2222060 | 0.78 | TP53 (0.47) | MEN1TP53PABPC1KMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL10641565 | 0.76 | MEN1 (0.41) | MEN1TP53PABPC1KMT2ASMN1; SMN2 | |
| SCHEMBL2193330 | 0.75 | KMT2A (0.43) | MEN1TP53PABPC1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519522-A2 | SUBSTITUTED IMIDAZOPYRIDINYL-AMINOPYRIDINE COMPOUNDS | ArQule, Inc. (US) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011082270-A2 | SUBSTITUTED IMIDAZOPYRIDINYL-AMINOPYRIDINE COMPOUNDS | ARQULE. INC. (US) | 2011-07-07 | — | — | WO | disclosed |