Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.31 |
| ▸ | CCNC | P24863 | 1/20 | 0.31 |
| ▸ | CDK8 | P49336 | 1/20 | 0.31 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.31 |
| ▸ | TTK | P33981 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19722 | 0.94 | GRM4 (0.32) | DGAT1CCNCCDK8GRM4 | |
| SCHEMBL15031463 | 0.94 | CFTR (0.33) | GRM4 | |
| SCHEMBL15007518 | 0.93 | GRM4 (0.31) | DGAT1CCNCCDK8GRM4 | |
| SCHEMBL15007191 | 0.87 | DGAT1 (0.31) | DGAT1CCNCCDK8GRM4 | |
| SCHEMBL20972 | 0.87 | CHEK1 (0.35) | CCNCCDK8GRM4TTK | |
| SCHEMBL21518 | 0.86 | GRM4 (0.32) | DGAT1CCNCCDK8GRM4 | |
| SCHEMBL19684 | 0.86 | GRM4 (0.32) | DGAT1CCNCCDK8GRM4 | |
| SCHEMBL20645 | 0.85 | GRM4 (0.32) | CCNCCDK8GRM4 | |
| SCHEMBL19940 | 0.85 | GRM4 (0.32) | CCNCCDK8GRM4 | |
| SCHEMBL15006953 | 0.85 | CHEK1 (0.32) | CCNCCDK8GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2608669-B1 | NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MERCK SHARP & DOHME (US) | 2016-06-22 | — | — | EP | disclosed |
| WO-2012027236-A1 | NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | SCHERING CORPORATION (US) | 2012-03-01 | — | — | WO | disclosed |