Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.65 |
| ▸ | NPC1 | O15118 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | TGM2 | P21980 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
| ▸ | CASP7 | P55210 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.49 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.49 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11060416 | 0.85 | GAA (0.49) | RAB9ANPC1MEN1KMT2AGAA | |
| SCHEMBL19707566 | 0.84 | GAA (0.65) | RAB9ANPC1MEN1KMT2AGAA | |
| SCHEMBL26761199 | 0.81 | ALDH1A1 (0.59) | RAB9ANPC1MEN1KMT2AGAA | |
| SCHEMBL10172932 | 0.81 | HSD17B10 (0.61) | RAB9ANPC1MEN1KMT2AGAA | |
| SCHEMBL15064987 | 0.81 | GAA (0.62) | RAB9ANPC1MEN1KMT2AGAA | |
| SCHEMBL23453326 | 0.80 | KMT2A (0.51) | RAB9ANPC1MEN1KMT2AGAA | |
| SCHEMBL11873457 | 0.80 | NPSR1 (0.61) | RAB9ANPC1MEN1KMT2AGAA | |
| SCHEMBL21116150 | 0.80 | KMT2A (0.71) | RAB9ANPC1MEN1KMT2AGAA | |
| SCHEMBL12932746 | 0.80 | RAB9A (0.59) | RAB9ANPC1MEN1KMT2AGAA | |
| SCHEMBL18232989 | 0.80 | HDAC3 (0.57) | RAB9ANPC1MEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3643308-B1 | COUMARIN-LIKE CYCLIC COMPOUND AS MEK INHIBITOR AND USE THEREOF | CSTONE PHARMACEUTICALS (KY) | 2021-05-19 | — | — | EP | disclosed |
| EP-3643308-A1 | COUMARIN-LIKE CYCLIC COMPOUND AS MEK INHIBITOR AND USE THEREOF | CSTONE PHARMACEUTICALS (KY) | 2020-04-29 | — | — | EP | disclosed |