Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.63 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TOP2A | P11388 | 2/20 | 0.40 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2738955 | 0.91 | KCNH2 (0.66) | KCNH2HRH3KDM4EALDH1A1LMNA | |
| SCHEMBL2738953 | 0.88 | KCNH2 (0.69) | KCNH2HRH3KDM4EALDH1A1LMNA | |
| SCHEMBL218555 | 0.87 | KCNH2 (0.65) | KCNH2HRH3KDM4EALDH1A1LMNA | |
| SCHEMBL2738957 | 0.86 | KCNH2 (0.60) | KCNH2HRH3KDM4EALDH1A1LMNA | |
| SCHEMBL2738956 | 0.85 | KCNH2 (0.62) | KCNH2HRH3KDM4EALDH1A1LMNA | |
| SCHEMBL8199125 | 0.85 | KCNH2 (0.74) | KCNH2HRH3KDM4EALDH1A1LMNA | |
| SCHEMBL12665467 | 0.81 | KCNH2 (0.70) | KCNH2HRH3KDM4EALDH1A1LMNA | |
| SCHEMBL10109120 | 0.81 | KCNH2 (0.70) | KCNH2HRH3KDM4EALDH1A1LMNA | |
| SCHEMBL22778993 | 0.80 | KCNH2 (0.62) | KCNH2HRH3KDM4EALDH1A1LMNA | |
| SCHEMBL26931558 | 0.80 | KCNH2 (0.62) | KCNH2HRH3KDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088918-B2 | Noncardiotoxic pharmaceutical compounds | WILLIAMSBURG HOLDINGS LLC (US) | 2012-01-03 | — | — | US | disclosed |
| CN-101432003-A | Non-cardiotoxic pharmaceutical compounds | BARBEAU DONALD L (US) | 2009-05-13 | — | — | CN | disclosed |
| US-20060035863-A1 | Noncardiotoxic pharmaceutical compounds | B&G PARTNERS, LLC | 2006-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060035863-A1 | Noncardiotoxic pharmaceutical compounds | KCNN3, TNNI3, TNNT2 | KCNH2 11/4885HRH3 1144/4885KDM4E 3018/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.