Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.62 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.62 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.61 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.60 |
| ▸ | FAAH | O00519 | 4/20 | 0.59 |
| ▸ | RPA1 | P27694 | 2/20 | 0.58 |
| ▸ | MGLL | Q99685 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | BCL2 | P10415 | 1/20 | 0.54 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.54 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9893959 | 0.94 | LMNA (0.66) | CA9LMNATP53GABRA2GABRB2 | |
| SCHEMBL1764934 | 0.94 | LMNA (0.59) | CA9LMNATP53GABRA2GABRB2 | |
| SCHEMBL9630738 | 0.90 | CA9 (0.77) | CA9TP53CHRNA7FAAHRPA1 | |
| SCHEMBL1765259 | 0.90 | LMNA (0.55) | CA9LMNATP53GABRA2GABRB2 | |
| SCHEMBL1765509 | 0.88 | CCKAR (0.60) | CA9LMNATP53GABRA2GABRB2 | |
| SCHEMBL1765252 | 0.88 | LMNA (0.53) | CA9LMNATP53GABRA2GABRB2 | |
| SCHEMBL1764994 | 0.88 | TP53 (0.55) | CA9LMNATP53GABRA2GABRB2 | |
| SCHEMBL1764959 | 0.87 | CHRNA7 (0.67) | CA9LMNATP53GABRA2GABRB2 | |
| SCHEMBL1764908 | 0.87 | FAAH (0.59) | CA9LMNATP53GABRA2GABRB2 | |
| SCHEMBL2193884 | 0.87 | TP53 (0.52) | CA9LMNATP53GABRA2GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2278965-B1 | SUBSTITUTED PYRAZOLAMIDES AND THE USE THEREOF | AICURIS GMBH & CO KG (DE) | 2013-11-13 | — | — | EP | disclosed |
| US-8314089-B2 | Substituted pyrazolamides and their use | AICURIS GMBH & CO. KG (DE) | 2012-11-20 | — | — | US | disclosed |
| US-8314089-B2 | Substituted pyrazolamides and their use | AICURIS GMBH & CO. KG (DE) | 2012-11-20 | — | — | US | disclosed |
| US-20110172207-A1 | SUBSTITUTED PYRAZOLAMIDES AND THEIR USE | AICURIS GMBH & CO. KG (DE) | 2011-07-14 | — | — | US | disclosed |
| US-20110172207-A1 | SUBSTITUTED PYRAZOLAMIDES AND THEIR USE | AICURIS GMBH & CO. KG (DE) | 2011-07-14 | — | — | US | disclosed |
| US-20110172207-A1 | SUBSTITUTED PYRAZOLAMIDES AND THEIR USE | AICURIS GMBH & CO. KG (DE) | 2011-07-14 | — | — | US | disclosed |
| WO-2009115252-A2 | SUBSTITUTED PYRAZOLAMIDES AND THE USE THEREOF | AICURIS GMBH & CO. KG (DE) | 2009-09-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110172207-A1 | SUBSTITUTED PYRAZOLAMIDES AND THEIR USE | CACNA1A, P2RX4, KCNH1 | CA9 1205/4885LMNA 2155/4885TP53 3813/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.