Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | CA7 | P43166 | 2/20 | 0.32 |
| ▸ | CA9 | Q16790 | 2/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22821220 | 0.85 | NOTUM (0.37) | SLC6A3SOS1ALDH1A1HTTKDM4E | |
| SCHEMBL29363398 | 0.85 | NOTUM (0.37) | SLC6A3SOS1ALDH1A1HTTKDM4E | |
| SCHEMBL29089695 | 0.83 | KDM4E (0.33) | ALDH1A1HTTKDM4ETSHRHSD17B10 | |
| SCHEMBL29089692 | 0.83 | ALDH1A1 (0.39) | ALDH1A1HTTKDM4ETSHRHSD17B10 | |
| SCHEMBL18878157 | 0.81 | CES2 (0.39) | SLC6A4SLC6A3SOS1ALDH1A1KDM4E | |
| SCHEMBL30296812 | 0.80 | SOS1 (0.41) | SLC6A4SLC6A3SOS1ALDH1A1KDM4E | |
| SCHEMBL3410570 | 0.80 | SOS1 (0.41) | SLC6A4SLC6A3SOS1ALDH1A1KDM4E | |
| SCHEMBL14719178 | 0.80 | KDM4E (0.37) | SLC6A4SLC6A3SOS1ALDH1A1HTT | |
| SCHEMBL21001493 | 0.79 | GAA (0.39) | SLC6A4SLC6A3SOS1ALDH1A1HTT | |
| SCHEMBL20766650 | 0.79 | KDM4E (0.42) | SLC6A4SLC6A3SOS1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11352338-B2 | Substituted isoindolinones | BIOTHERYX, INC. (US) | 2022-06-07 | — | — | US | disclosed |
| EP-3880669-A1 | SUBSTITUTED ISOINDOLINONES | Biotheryx, Inc. (US) | 2021-09-22 | — | — | EP | disclosed |
| CN-113423701-A | Substituted isoindolinones | 拜欧斯瑞克斯公司 | 2021-09-21 | — | — | CN | disclosed |
| US-10844039-B2 | Substituted isoindolinones | BIOTHERYX, INC. (US) | 2020-11-24 | — | — | US | disclosed |
| US-20200325114-A1 | SUBSTITUTED ISOINDOLINONES | BIOTHERYX, INC. (US) | 2020-10-15 | — | — | US | disclosed |
| WO-2020102195-A1 | SUBSTITUTED ISOINDOLINONES | BIOTHERYX, INC. (US) | 2020-05-22 | — | — | WO | disclosed |
| US-20200148663-A1 | SUBSTITUTED ISOINDOLINONES | BIOTHERYX, INC. | 2020-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200148663-A1 | SUBSTITUTED ISOINDOLINONES | BRCA1, FANCI, GOT2 | SLC6A4 3792/4885SLC6A3 4208/4885SOS1 3907/4885 |
| US-10844039-B2 | Substituted isoindolinones | BRCA1, FANCI, GOT2 | SLC6A4 3792/4885SLC6A3 4208/4885SOS1 3907/4885 |
| US-20200325114-A1 | SUBSTITUTED ISOINDOLINONES | BRCA1, FANCI, GOT2 | SLC6A4 3792/4885SLC6A3 4208/4885SOS1 3907/4885 |
| US-11352338-B2 | Substituted isoindolinones | BRCA1, FANCI, GOT2 | SLC6A4 3792/4885SLC6A3 4208/4885SOS1 3907/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.