Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | RGS12 | O14924 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27555655 | 0.89 | TRPA1 (0.48) | TRPA1LMNAKDM4EALDH1A1ADRA2C | |
| Ethylene Glycol SCHEMBL2680753 | 0.87 | TRPA1 (0.47) | TRPA1LMNAKDM4EALDH1A1ADRA2C | |
| SCHEMBL198133 | 0.84 | HCAR2 (0.45) | LMNAKDM4EALDH1A1ADRA2CADRA2A | |
| Hydrochloric Acid SCHEMBL28273439 | 0.82 | ALDH1A1 (0.44) | LMNAKDM4EALDH1A1ADRA2CADRA2A | |
| Phosphine SCHEMBL20897413 | 0.82 | CYP2D6 (0.46) | LMNAKDM4EALDH1A1ADRA2CADRA2A | |
| Ammonia Solution, Strong SCHEMBL27871924 | 0.82 | HCAR2 (0.44) | LMNAKDM4EALDH1A1ADRA2CADRA2A | |
| SCHEMBL8602813 | 0.82 | GSR (0.49) | TRPA1LMNAKDM4EALDH1A1ADRA2C | |
| Isopropylbenzene SCHEMBL9272048 | 0.80 | TRPA1 (0.52) | TRPA1LMNAKDM4EALDH1A1ADRA2C | |
| SCHEMBL31612040 | 0.80 | LMNA (0.46) | LMNAKDM4EALDH1A1ADRA2CADRA2A | |
| SCHEMBL4323419 | 0.80 | TRPA1 (0.44) | TRPA1LMNAKDM4EALDH1A1ADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11124746-B2 | Post CMP cleaning composition | ENTEGRIS, INC. (US) | 2021-09-21 | — | — | US | claimed |
| US-20200148979-A1 | POST CMP CLEANING COMPOSITION | MORGAN STANLEY SENIOR FUNDING, INC., AS COLLATERAL AGENT | 2020-05-14 | — | — | US | claimed |