Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 3/20 | 0.89 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL524777 | 0.97 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL22686437 | 0.97 | CA4 (0.94) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL42945 | 0.97 | CA4 (0.94) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL29587574 | 0.97 | CA4 (0.94) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL1291555 | 0.97 | CA4 (0.94) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL23012792 | 0.94 | CA4 (0.89) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL20668547 | 0.94 | CA4 (0.89) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL1231114 | 0.94 | CA4 (0.89) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL20668544 | 0.94 | CA4 (0.89) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL9171055 | 0.94 | CA4 (0.89) | CA4ALDH1A1CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 6078 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122071001-A | Catalyst and method for preparing organic carboxylic acid by catalytic oxidation of aldehyde | 万华化学集团股份有限公司 | 2026-05-22 | — | — | CN | claimed |
| US-20260130785-A1 | SYSTEMS AND METHODS INCLUDING LUBRICANTS FOR CONVEYANCE OF STOOL | LIQUIGLIDE INC (US) | 2026-05-14 | — | — | US | claimed |
| CN-122005437-A | Copper ion hydrogel and preparation method and application thereof | 陕西科技大学 | 2026-05-12 | — | — | CN | claimed |
| EP-4724077-A1 | COMBINATION OF BACTERIAL STRAINS TO INHIBIT PATHOGENS IN ANIMALS | Phibro Animal Health Corporation (US) | 2026-04-15 | — | — | EP | claimed |
| EP-4719294-A1 | SYSTEMS AND METHODS INCLUDING LUBRICANTS FOR CONVEYANCE OF STOOL | Liquiglide Inc. (US) | 2026-04-08 | — | — | EP | claimed |
| US-20260092186-A1 | METAL NANOPARTICLE INK | UNIV IOWA STATE RES FOUND INC (US) | 2026-04-02 | — | — | US | claimed |
| US-20260077020-A1 | ORAL PEPTIDE PHARMACEUTICAL COMPOSITION THAT FACILITATES ENHANCED ORAL ABSORPTION | LE ROUX DANIELLE MARIE (US) | 2026-03-19 | — | — | US | claimed |
| US-20260035583-A1 | IN-SITU THERMALLY ACTIVATED IONIC INK, AND PREPARATION METHOD AND APPLICATION THEREOF | UNIV GUANGDONG TECHNOLOGY (CN) | 2026-02-05 | — | — | US | claimed |
| US-12516205-B2 | Metal nanoparticle ink | IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2026-01-06 | — | — | US | claimed |
| US-12447237-B2 | Application of antimicrobial agents to medical devices | C. R. BARD, INC. (US) | 2025-10-21 | — | — | US | claimed |
| US-4332791-A | NONDISCOLORING | BLENDAX-WERKE R. SCHNEIDER GMBH & CO. (DE) | 1982-06-01 | — | — | US | claimed |
| EP-0004570-B1 | THIOL ESTERS, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND A PROCESS FOR PREPARING CEPHALOSPORIN COMPOUNDS USING THE SAME | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1982-04-14 | — | — | EP | claimed |
| US-4308118-A | POLYEPOXIDES; IRRADIATION POLYMERIZATION | GENERAL ELECTRIC COMPANY (US) | 1981-12-29 | — | — | US | claimed |
| US-4275190-A | VARNISHES AND FREE-FLOWING POWDERS STABILIZED WITH CARBOXYLATED OR HYDROXYLATED ACRYLONITRILE-BUTADIENE COPOLYMER | GENERAL ELECTRIC COMPANY (US) | 1981-06-23 | — | — | US | claimed |
| US-4254214-A | BLACK, REDUCTION OF COPPER SALT OR COMPLEX TO COPPER | FUJI PHOTO FILM CO., LTD. (JP) | 1981-03-03 | — | — | US | claimed |
| US-4238563-A | COPPER SALT, FERRICYANIDE SALT, SEQUESTERING AGENT | MINRAD CORPORATION (US) | 1980-12-09 | — | — | US | claimed |
| US-4173453-A | Topical hair coloring formulation in the form of suspension, lotion and cream | CDC Research Inc. (US) | 1979-11-06 | — | — | US | claimed |
| EP-0004570-A1 | Thiol esters, process for their preparation, pharmaceutical compositions containing them and a process for preparing cephalosporin compounds using the same | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1979-10-17 | — | — | EP | claimed |
| US-4007316-A | COATED WITH COPPER OXALATE, SULFUR, CARBON | THE MAGNAVOX COMPANY (US) | 1977-02-08 | — | — | US | claimed |
| US-3997525-A | Tetra-125 iodo-di-tyramine of digitalis derivative and process for making the same | BIO-TEC, INC. (US) | 1976-12-14 | — | — | US | claimed |