Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SSTR4 | P31391 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
| ▸ | HTR3B | O95264 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.39 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.39 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18922591 | 0.85 | SMN1; SMN2 (0.41) | SMN1; SMN2HPGDALDH1A1L3MBTL1SCN10A | |
| SCHEMBL10248233 | 0.81 | ALDH1A1 (0.61) | SMN1; SMN2HPGDALDH1A1SSTR4L3MBTL1 | |
| SCHEMBL10248397 | 0.78 | SMN1; SMN2 (0.45) | SMN1; SMN2HPGDALDH1A1SSTR4L3MBTL1 | |
| SCHEMBL23843237 | 0.76 | ALDH1A1 (0.54) | SMN1; SMN2HPGDALDH1A1SSTR4TDP1 | |
| SCHEMBL18862125 | 0.74 | ALDH1A1 (0.39) | SMN1; SMN2HPGDALDH1A1SSTR4TDP1 | |
| SCHEMBL20863743 | 0.73 | TUBB4A (0.41) | SMN1; SMN2ALDH1A1L3MBTL1LMNARAB9A | |
| SCHEMBL18727156 | 0.73 | ALDH1A1 (0.51) | SMN1; SMN2ALDH1A1L3MBTL1SCN10AKCNH2 | |
| SCHEMBL868599 | 0.72 | SMN1; SMN2 (0.43) | SMN1; SMN2HPGDALDH1A1L3MBTL1SCN10A | |
| SCHEMBL18727321 | 0.71 | ALDH1A1 (0.42) | SMN1; SMN2HPGDALDH1A1L3MBTL1SCN10A | |
| SCHEMBL23776494 | 0.71 | TUBB4A (0.53) | SMN1; SMN2ALDH1A1L3MBTL1SCN10AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200113923-A1 | DOT1L INHIBITORS FOR USE IN THE TREATMENT OF LEUKEMIA | Epizyme, Inc. | 2020-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200113923-A1 | DOT1L INHIBITORS FOR USE IN THE TREATMENT OF LEUKEMIA | DOT1L, CARM1, MCL1 | SMN1; SMN2 1819/4885HPGD 3590/4885ALDH1A1 1884/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.