Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR2 | O95136 | 11/20 | 0.40 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21941074 | 0.89 | S1PR2 (0.39) | S1PR2NLRP3MAPK1 | |
| SCHEMBL21940475 | 0.82 | S1PR2 (0.42) | S1PR2 | |
| SCHEMBL21940255 | 0.81 | S1PR2 (0.37) | S1PR2 | |
| SCHEMBL21940282 | 0.80 | S1PR2 (0.41) | S1PR2 | |
| SCHEMBL20606887 | 0.79 | S1PR2 (0.50) | S1PR2ALDH1A1 | |
| SCHEMBL21940786 | 0.73 | TGFBR1 (0.32) | — | |
| SCHEMBL21941070 | 0.71 | S1PR2 (0.37) | S1PR2MAPK1 | |
| SCHEMBL20606814 | 0.69 | S1PR2 (0.42) | S1PR2ALDH1A1 | |
| SCHEMBL21940269 | 0.69 | S1PR2 (0.34) | S1PR2MAPT | |
| SCHEMBL20606770 | 0.66 | ACHE (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3423445-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS | GALAPAGOS NV (BE) | 2020-04-01 | — | — | EP | disclosed |