Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | BCL6 | P41182 | 1/20 | 0.31 |
| ▸ | EDNRA | P25101 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20606943 | 0.74 | ALDH1A1 (0.37) | ALDH1A1MEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL14135244 | 0.73 | KMO (0.34) | — | |
| SCHEMBL21940287 | 0.71 | KMT2A (0.38) | MEN1KMT2AGAAMAPTEDNRA | |
| SCHEMBL10368496 | 0.69 | NOTUM (0.31) | ALDH1A1 | |
| SCHEMBL21940485 | 0.69 | KDM4E (0.38) | ALDH1A1KMT2AHPGDKDM4EMAPT | |
| SCHEMBL25363142 | 0.65 | KMO (0.33) | ALDH1A1CYP1A2CYP2C9CYP2C19KDM4E | |
| SCHEMBL10373605 | 0.65 | — | — | |
| SCHEMBL21940789 | 0.64 | PANK3 (0.32) | — | |
| SCHEMBL5235265 | 0.63 | TSHR (0.49) | ALDH1A1MEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL21940281 | 0.63 | AR (0.37) | ALDH1A1MEN1KMT2ACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3423445-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS | GALAPAGOS NV (BE) | 2020-04-01 | — | — | EP | disclosed |