Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | CASP6 | P55212 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9173967 | 0.82 | GAA (0.50) | GAAALDH1A1MAPTHTTKMT2A | |
| SCHEMBL12963726 | 0.79 | GAA (0.51) | GAAALDH1A1MAPTHTTADRA1D | |
| SCHEMBL9988787 | 0.78 | GAA (0.81) | GAAALDH1A1MAPTHTTKMT2A | |
| SCHEMBL20512947 | 0.75 | GAA (0.54) | GAAALDH1A1MAPTHTTADRA1D | |
| SCHEMBL10499067 | 0.75 | HTT (0.39) | GAAALDH1A1MAPTHTTKMT2A | |
| SCHEMBL17847346 | 0.74 | GAA (0.50) | GAAALDH1A1MAPTHTTADRA1D | |
| SCHEMBL10624864 | 0.74 | GAA (0.59) | GAAALDH1A1MAPTHTTKMT2A | |
| SCHEMBL13165681 | 0.74 | GAA (0.53) | GAAALDH1A1MAPTHTTADRA1D | |
| SCHEMBL29153467 | 0.74 | GAA (0.53) | GAAALDH1A1MAPTHTTADRA1D | |
| Hydrochloric Acid SCHEMBL14999773 | 0.74 | GAA (0.53) | GAAALDH1A1MAPTHTTADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110172255-A1 | Condensed N-Heterocyclic Compounds and their Use as CRF Receptor Antagonists | SB PHARMCO PUERTO RICO INC | 2011-07-14 | — | — | US | claimed |
| US-20110172255-A1 | Condensed N-Heterocyclic Compounds and their Use as CRF Receptor Antagonists | SB PHARMCO PUERTO RICO INC | 2011-07-14 | — | — | US | disclosed |
| EP-1611133-B1 | CONDENSED N-HETEROCYCLIC COMPOUND AND USE THEREOFF AS CRF RECEPTOR ANTAGONIST | SMITHKLINE BEECHAM CORK LTD (IE) | 2010-07-07 | — | — | EP | disclosed |
| EP-2186813-A1 | Condensed N-heterocyclic compounds and their use as CRF receptor antagonists | SmithKline Beecham (Cork) Limited (IE) | 2010-05-19 | — | — | EP | disclosed |
| US-20090023757-A1 | PROCESS FOR PREPARING BICYCLIC COMPOUNDS | SMITHKLINE BEECHAM (CORK) LIMITED (IE) | 2009-01-22 | — | — | US | disclosed |
| US-20080312444-A1 | Process for Preparing Bicyclic Compounds | SMITHKLINE BEECHAM (CORK) LIMITED (IE) | 2008-12-18 | — | — | US | disclosed |
| US-7427630-B2 | Condensed N-heterocyclic compounds and their use as CRF receptor antagonists | SB PHARMACO PUERTO RICO INC. (US) | 2008-09-23 | — | — | US | disclosed |
| EP-1874771-A2 | PROCESS FOR PREPARING BICYCLIC COMPOUNDS | SB Pharmco Puerto Rico Inc. (PR) | 2008-01-09 | — | — | EP | disclosed |
| EP-1869039-A2 | PROCESS FOR PREPARING BICYCLIC COMPOUNDS | SB Pharmco Puerto Rico Inc. (PR) | 2007-12-26 | — | — | EP | disclosed |
| US-20070004708-A1 | Condensed n-heterocyclic compounds and their use as crf receptor antagonists | NEUROCRINE BIOSCIENCES, INC. | 2007-01-04 | — | — | US | disclosed |
| WO-2006108693-A2 | PROCESS FOR PREPARING BICYCLIC COMPOUNDS | SB PHARMCO PUERTO RICO INC (US) | 2006-10-19 | — | — | WO | disclosed |
| WO-2006108689-A2 | PROCESS FOR PREPARING BICYCLIC COMPOUNDS | SB PHARMCO PUERTO RICO INC (US) | 2006-10-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110172255-A1 | Condensed N-Heterocyclic Compounds and their Use as CRF Receptor Antagonists | CRH, CRHR1, CRHR2 | GAA 3259/4885ALDH1A1 3090/4885MAPT 2636/4885 |
| US-20080312444-A1 | Process for Preparing Bicyclic Compounds | CRH, CRHR1, CRHR2 | GAA 2663/4885ALDH1A1 1631/4885MAPT 3499/4885 |
| US-20070004708-A1 | Condensed n-heterocyclic compounds and their use as crf receptor antagonists | CRHR2, NR3C2, CRHR1 | GAA 4779/4885ALDH1A1 4153/4885MAPT 4811/4885 |
| US-20090023757-A1 | PROCESS FOR PREPARING BICYCLIC COMPOUNDS | CRH, CRHR1, CRHR2 | GAA 2663/4885ALDH1A1 1631/4885MAPT 3499/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.