Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17882433 | 0.84 | MDM2 (0.36) | DPP4MEN1KMT2AHPGDMDM2 | |
| SCHEMBL17882436 | 0.82 | ABCG2 (0.39) | MEN1KMT2AHPGDALDH1A1MAPT | |
| SCHEMBL21941975 | 0.81 | KDM4E (0.31) | ALDH1A1MAPTKDM4ECYP3A4CYP1A2 | |
| SCHEMBL21942427 | 0.81 | MEN1 (0.40) | DPP4MEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL17870867 | 0.80 | TSHR (0.41) | MEN1KMT2AALDH1A1KDM4ELMNA | |
| SCHEMBL17882360 | 0.78 | ADORA2A (0.38) | MEN1KMT2AMAPTLMNAADORA2A | |
| SCHEMBL21942266 | 0.78 | ESR1 (0.41) | HPGDLMNAHTTMDM2 | |
| SCHEMBL17882355 | 0.77 | PDE6D (0.36) | MEN1KMT2AHPGDALDH1A1MAPT | |
| SCHEMBL17882401 | 0.76 | PDE6D (0.41) | MEN1KMT2AHPGDALDH1A1MAPT | |
| SCHEMBL16884747 | 0.73 | ALDH1A1 (0.39) | MEN1KMT2AHPGDALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3237387-B1 | HETEROCYCLIC COMPOUNDS WITH DIBENZAZAPINE STRCTURES | MERCK PATENT GMBH (DE) | 2023-09-06 | — | — | EP | disclosed |
| US-10636979-B2 | Heterocyclic compounds with dibenzazapine structures | MERCK PATENT GMBH (DE) | 2020-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10636979-B2 | Heterocyclic compounds with dibenzazapine structures | DDT, MAOA, MAOB | DPP4 514/4885MEN1 4457/4885KMT2A 678/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.