Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.33 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17882362 | 0.80 | DPP4 (0.47) | TSHRKDM4EGAAMEN1KMT2A | |
| SCHEMBL21941983 | 0.80 | DPP4 (0.36) | TSHRKDM4EMEN1KMT2AMAPK14 | |
| SCHEMBL21942500 | 0.80 | GAA (0.48) | KDM4EGAAMEN1KMT2AALDH1A1 | |
| SCHEMBL21941975 | 0.79 | KDM4E (0.31) | KDM4EMAPK14ALDH1A1L3MBTL1CYP3A4 | |
| SCHEMBL13314104 | 0.75 | CES1 (0.39) | TSHRKDM4EGAAMEN1KMT2A | |
| SCHEMBL13941868 | 0.75 | MEN1 (0.38) | TSHRGAAMEN1KMT2AMAPK14 | |
| SCHEMBL17882411 | 0.74 | ALDH1A1 (0.43) | GAAMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL30596240 | 0.66 | CES1 (0.58) | TSHRGAAMEN1KMT2AMAPK14 | |
| SCHEMBL11409331 | 0.66 | CES1 (0.58) | TSHRGAAMEN1KMT2AMAPK14 | |
| SCHEMBL30596238 | 0.66 | CES1 (0.58) | TSHRGAAMEN1KMT2AMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3237387-B1 | HETEROCYCLIC COMPOUNDS WITH DIBENZAZAPINE STRCTURES | MERCK PATENT GMBH (DE) | 2023-09-06 | — | — | EP | disclosed |
| US-10636979-B2 | Heterocyclic compounds with dibenzazapine structures | MERCK PATENT GMBH (DE) | 2020-04-28 | — | — | US | disclosed |
| EP-3237387-A1 | HETEROCYCLIC COMPOUNDS WITH DIBENZAZAPINE STRCTURES | Merck Patent GmbH (DE) | 2017-11-01 | — | — | EP | disclosed |
| WO-2016102039-A1 | HETEROCYCLIC COMPOUNDS WITH DIBENZAZAPINE STRCTURES | MERCK PATENT GMBH (DE) | 2016-06-30 | — | — | WO | disclosed |
| WO-2016102039-A1 | HETEROCYCLIC COMPOUNDS WITH DIBENZAZAPINE STRCTURES | MERCK PATENT GMBH (DE) | 2016-06-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10636979-B2 | Heterocyclic compounds with dibenzazapine structures | DDT, MAOA, MAOB | TSHR 2917/4885KDM4E 1175/4885GAA 1138/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.