SCHEMBL21944199

SCHEMBL21944199

Cc1ccccc1-c1cccc(-c2ccc(N(c3ccc(-c4ccc(-c5ccccc5)cc4)cc3)c3ccc(-c4cccc(-c5ccccc5)c4)cc3)cc2)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR7 P34969 3/20 0.46
MCL1 Q07820 1/20 0.44
CTSD P07339 1/20 0.43
BACE1 P56817 1/20 0.43
GRIA1 P42261 1/20 0.41
CACNG8 Q8WXS5 1/20 0.41
HTR1A P08908 1/20 0.41
NR1H4 Q96RI1 1/20 0.40
EDNRB P24530 1/20 0.40
EDNRA P25101 1/20 0.40
TRPA1 O75762 1/20 0.40
ALDH1A1 P00352 2/20 0.39
TSHR P16473 2/20 0.39
CYP1A2 P05177 1/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2D6 P10635 1/20 0.39
CYP2C9 P11712 1/20 0.39
MAPK1 P28482 1/20 0.39
CYP2C19 P33261 1/20 0.39
CLK4 Q9HAZ1 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19393444 0.93 MCL1 (0.45) HTR7MCL1CTSDBACE1GRIA1
SCHEMBL15870792 0.89 ENPP3 (0.46) HTR7MCL1CTSDBACE1GRIA1
SCHEMBL19942893 0.89 HTR7 (0.43) HTR7MCL1CTSDBACE1GRIA1
SCHEMBL21250647 0.88 ESR2 (0.47) HTR7MCL1CTSDBACE1GRIA1
SCHEMBL22211041 0.87 ENPP3 (0.45) HTR7MCL1CTSDBACE1GRIA1
SCHEMBL16385673 0.87 SLC6A9 (0.38) HTR7MCL1CTSDBACE1ALDH1A1
SCHEMBL22698813 0.87 HTR7 (0.55) HTR7MCL1CTSDBACE1GRIA1
SCHEMBL17881830 0.86 MAPT (0.39) HTR7MCL1CTSDBACE1EDNRB
SCHEMBL22079657 0.85 MEN1 (0.41) BACE1ALDH1A1CYP1A2CYP3A4CYP2D6
SCHEMBL22079983 0.85 MEN1 (0.41) BACE1ALDH1A1CYP1A2CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3018120-B1 COMPOUND, MATERIAL FOR ORGANIC ELECTROLUMINESCENT DEVICE, ORGANIC ELECTROLUMINESCENT DEVICE, AND ELECTRONIC EQUIPMENT IDEMITSU KOSAN CO (JP) 2020-04-15 EP disclosed