Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.69 |
| ▸ | GAA | P10253 | 1/20 | 0.69 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.45 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | PTPRB | P23467 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13571398 | 0.87 | TSHR (0.84) | TSHRGAAHTTRAB9AKMT2A | |
| SCHEMBL28807373 | 0.80 | GAA (0.70) | TSHRGAAHTTRAB9APOLB | |
| SCHEMBL2194496 | 0.79 | TSHR (0.70) | TSHRGAAHTTRAB9AKMT2A | |
| SCHEMBL25911204 | 0.77 | PKM (0.57) | TSHRGAAPKMRAB9AAGTR1 | |
| SCHEMBL3044246 | 0.77 | RAB9A (0.57) | TSHRGAAMAPK14HTTRAB9A | |
| SCHEMBL27759939 | 0.77 | KMT2A (0.56) | PKMRAB9AKMT2AALDH1A1MAPT | |
| SCHEMBL6827496 | 0.76 | RAB9A (0.53) | HTTRAB9AKMT2AALDH1A1MEN1 | |
| SCHEMBL24069158 | 0.74 | PKM (0.55) | TSHRHTTPKMKMT2AALDH1A1 | |
| SCHEMBL30209753 | 0.74 | PKM (0.55) | TSHRHTTPKMKMT2AALDH1A1 | |
| SCHEMBL25911202 | 0.74 | PKM (0.54) | TSHRGAAPKMRAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519522-A2 | SUBSTITUTED IMIDAZOPYRIDINYL-AMINOPYRIDINE COMPOUNDS | ArQule, Inc. (US) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011082270-A2 | SUBSTITUTED IMIDAZOPYRIDINYL-AMINOPYRIDINE COMPOUNDS | ARQULE. INC. (US) | 2011-07-07 | — | — | WO | disclosed |