Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.70 |
| ▸ | GAA | P10253 | 2/20 | 0.70 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | STAT3 | P40763 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13571398 | 0.91 | TSHR (0.84) | TSHRGAAKMT2ANPC1MEN1 | |
| SCHEMBL28807373 | 0.83 | GAA (0.70) | TSHRGAAKMT2ANPC1HTT | |
| SCHEMBL2194451 | 0.79 | TSHR (0.69) | TSHRGAAKMT2AMEN1HTT | |
| SCHEMBL3060251 | 0.78 | TSHR (0.71) | TSHRGAAKMT2ANPC1MEN1 | |
| SCHEMBL22289326 | 0.76 | GAA (0.73) | TSHRGAAKMT2ANPC1HTT | |
| SCHEMBL1336782 | 0.76 | GAA (0.60) | TSHRGAAKMT2ANPC1HTT | |
| SCHEMBL8332050 | 0.75 | KMT2A (0.71) | TSHRGAAKMT2ANPC1MEN1 | |
| SCHEMBL5907003 | 0.74 | ALDH1A1 (0.54) | TSHRGAACHRM3NPC1HTT | |
| SCHEMBL14908642 | 0.72 | SMN1; SMN2 (0.49) | TSHRGAANPC1HTTRAB9A | |
| SCHEMBL14720449 | 0.72 | CHRM3 (0.52) | TSHRGAACHRM3KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519522-A2 | SUBSTITUTED IMIDAZOPYRIDINYL-AMINOPYRIDINE COMPOUNDS | ArQule, Inc. (US) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011082270-A2 | SUBSTITUTED IMIDAZOPYRIDINYL-AMINOPYRIDINE COMPOUNDS | ARQULE. INC. (US) | 2011-07-07 | — | — | WO | disclosed |