⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29149 | 0.69 | — | — | |
| SCHEMBL20258271 | 0.66 | — | — | |
| SCHEMBL7831853 | 0.62 | — | — | |
| SCHEMBL29355782 | 0.58 | — | — | |
| SCHEMBL29900091 | 0.58 | — | — | |
| SCHEMBL659548 | 0.58 | — | — | |
| SCHEMBL12721329 | 0.57 | — | — | |
| Thiophene SCHEMBL15754567 | 0.57 | GPR35 (0.33) | — | |
| Thiophene SCHEMBL716369 | 0.57 | GPR35 (0.33) | — | |
| SCHEMBL4579663 | 0.56 | SLC6A3 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 182 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111233850-A | Naphthol derivative containing benzothiazole amino and heteroaryl, preparation method and application thereof | 南开大学 | 2020-06-05 | — | — | CN | claimed |
| EP-2336315-B1 | Enzymatic encoding methods for efficient synthesis of large libraries | NUEVOLUTION AS (DK) | 2017-07-19 | — | — | EP | claimed |
| US-20120065203-A1 | Methods of Reducing Serum Glucose and Triglyceride Levels and for Inhibiting Angiogenesis Using Substituted Indolealkanoic Acids | THE INSTITUTE FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2012-03-15 | — | — | US | claimed |
| EP-2336315-A2 | Enzymatic encoding methods for efficient synthesis of large libraries | Nuevolution A/S (DK) | 2011-06-22 | — | — | EP | claimed |
| US-20090163535-A1 | Substituted Heteroarylalkanoic Acids | THE INSTITUES FOR PHARMACEUTICAL DISCOVERY, INC. (US) | 2009-06-25 | — | — | US | claimed |
| US-20080214540-A1 | 3-[(phenyl or benzothiazol-2-yl)methyl]indole-N-acetic acids and esters; analgesics; aldose reductase inhibitors; diabetes complications including cataracts, retinopathy, nephropathy, and neuropathy; side effect reduction | THE INSTITUTE FOR PHARMACEUTICAL DISCOVERY, LLC | 2008-09-04 | — | — | US | claimed |
| US-20070093530-A1 | SUBSTITUTED INDOLEALKANOIC ACIDS | THE INSTITUTE FOR PHARMACEUTICAL DISCOVERY, LLC | 2007-04-26 | — | — | US | claimed |
| US-20060074114-A1 | Methods of reducing serum glucose and triglyceride levels and for inhibiting angiogenesis using substituted indolealkanoic acids | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, INC. | 2006-04-06 | — | — | US | claimed |
| US-6964980-B2 | Method of reducing serum glucose and triglyceride levels and for inhibiting angiogenesis using substitute indolealkanoic acids | THE INSTITUTE FOR PHARMACEUTICAL DISCOVERY, INC. (US) | 2005-11-15 | — | — | US | claimed |
| US-20040235933-A1 | Substituted indolealkanoic acids | THE INSTITUTE FOR PHARMACEUTICAL DISCOVERY LLC | 2004-11-25 | — | — | US | claimed |
| CN-1296485-A | Substituted indolealkanoic acids | INST FOR PHARM DISCOVERY INC (US) | 2001-05-23 | — | — | CN | claimed |
| EP-1066283-A2 | SUBSTITUTED INDOLEALKANOIC ACIDS | The Institutes for Pharmaceutical Discovery, Inc. (US) | 2001-01-10 | — | — | EP | claimed |
| WO-2000032180-A2 | ANTIHYPERTRIGLYCERIDEMIC, ANTIHYPERGLYCEMIC, ANTI-ANGIOGENIC AND WOUND HEALING SUBSTITUTED INDOLEALKANOIC ACIDS | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, INC. (US) | 2000-06-08 | — | — | WO | claimed |
| WO-1999050268-A2 | SUBSTITUTED INDOLEALKANOIC ACIDS | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, INC. (US) | 1999-10-07 | — | — | WO | claimed |
| EP-0213295-B1 | THIENO-1,2-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1991-04-10 | — | — | EP | claimed |
| US-4939140-A | ALDOSE REDUCTASE INHIBITORS | PFIZER INC. (US) | 1990-07-03 | — | — | US | claimed |
| CN-1035116-A | Heterocyclic type oxo-2 guanidine-acetic acid | PFIZER (US) | 1989-08-30 | — | — | CN | claimed |
| EP-0322153-A2 | Heterocyclic oxophtalazinyl acetic acids | PFIZER INC. (US) | 1989-06-28 | — | — | EP | claimed |
| US-4801591-A | 2-alkenylene-thieno-1,2-thiazole derivatives with lipid-lowering activity | CHEMIE-LINZ AKTIENGESELLSCHAET (AT) | 1989-01-31 | — | — | US | claimed |
| US-4587345-A | Process for preparing thieno-fused heterocyclic anti-ulcer agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1986-05-06 | — | — | US | claimed |