Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2B | P67870 | 8/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.50 |
| ▸ | CSNK2A1 | P68400 | 8/20 | 0.49 |
| ▸ | CSNK2A2 | P19784 | 7/20 | 0.49 |
| ▸ | CDK2 | P24941 | 5/20 | 0.47 |
| ▸ | GSK3B | P49841 | 3/20 | 0.47 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.47 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.47 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.45 |
| ▸ | CDK9 | P50750 | 3/20 | 0.45 |
| ▸ | CDK1 | P06493 | 2/20 | 0.45 |
| ▸ | CDK4 | P11802 | 2/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.45 |
| ▸ | CCND1 | P24385 | 2/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.45 |
| ▸ | CDK7 | P50613 | 2/20 | 0.45 |
| ▸ | CCNH | P51946 | 2/20 | 0.45 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.45 |
| ▸ | CDK3 | Q00526 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21877776 | 0.86 | CDK2 (0.64) | CSNK2BKCNH2CSNK2A1CSNK2A2CDK2 | |
| SCHEMBL21877674 | 0.80 | CDK2 (0.43) | CSNK2BKCNH2CSNK2A1CSNK2A2CDK2 | |
| SCHEMBL24174228 | 0.79 | CDK2 (0.50) | CSNK2BCSNK2A1CSNK2A2CDK2GSK3B | |
| SCHEMBL23992330 | 0.78 | CDK9 (0.57) | KCNH2CDK2CCNT1CDK9CDK1 | |
| SCHEMBL26874317 | 0.73 | CCNT1 (0.60) | CSNK2BCDK2GSK3BCCNT1CDK9 | |
| SCHEMBL26872835 | 0.73 | CDK2 (0.46) | CSNK2BCSNK2A2CDK2GSK3BCCNT1 | |
| SCHEMBL24418649 | 0.73 | CCNT1 (0.46) | CSNK2BCSNK2A1CSNK2A2CDK2GSK3B | |
| SCHEMBL26873523 | 0.72 | CCNT1 (0.45) | CSNK2BCSNK2A1CSNK2A2CDK2GSK3B | |
| SCHEMBL33377999 | 0.69 | CSNK2B (0.60) | CSNK2BCDK2GSK3BCCNT1CDK9 | |
| SCHEMBL22899498 | 0.69 | RAB9A (0.51) | CSNK2BKCNH2CSNK2A1CDK2CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220002305-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CDK9 ACTIVITY | Kronos Bio, Inc. (US) | 2022-01-06 | — | — | US | disclosed |
| US-11155560-B2 | Substituted pyrazolo[1,5-a]pyrimidines for modulating CDK9 activity | Kronos Bio, Inc. (US) | 2021-10-26 | — | — | US | disclosed |
| US-20200131189-A1 | Compounds, Compositions, and Methods for Modulating CDK9 Activity | IGNOTA LABS LIMITED (GB) | 2020-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200131189-A1 | Compounds, Compositions, and Methods for Modulating CDK9 Activity | CDK9, CDK19, CDK7 | CSNK2B 98/4885KCNH2 3335/4885CSNK2A1 99/4885 |
| US-20220002305-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CDK9 ACTIVITY | CDK9, CDK19, CDK7 | CSNK2B 98/4885KCNH2 3335/4885CSNK2A1 99/4885 |
| US-11155560-B2 | Substituted pyrazolo[1,5-a]pyrimidines for modulating CDK9 activity | CDK9, CDK19, CDK7 | CSNK2B 342/4885KCNH2 3293/4885CSNK2A1 285/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.