Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 6/20 | 0.50 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.50 |
| ▸ | CDK9 | P50750 | 4/20 | 0.50 |
| ▸ | CDK1 | P06493 | 2/20 | 0.50 |
| ▸ | CDK4 | P11802 | 2/20 | 0.50 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.50 |
| ▸ | CCND1 | P24385 | 2/20 | 0.50 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.50 |
| ▸ | CDK7 | P50613 | 2/20 | 0.50 |
| ▸ | CCNH | P51946 | 2/20 | 0.50 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.50 |
| ▸ | CDK3 | Q00526 | 2/20 | 0.50 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.50 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.50 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.50 |
| ▸ | CCNC | P24863 | 1/20 | 0.50 |
| ▸ | CDK8 | P49336 | 1/20 | 0.50 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22899498 | 0.86 | RAB9A (0.51) | CDK2CCNT1CDK9CDK1CDK4 | |
| SCHEMBL22899497 | 0.82 | CDK2 (0.46) | CDK2CCNT1CDK9CDK1CDK4 | |
| SCHEMBL26873523 | 0.81 | CCNT1 (0.45) | CDK2CCNT1CDK9CDK1CDK4 | |
| SCHEMBL26872835 | 0.79 | CDK2 (0.46) | CDK2CCNT1CDK9CDK1CDK4 | |
| SCHEMBL26874317 | 0.79 | CCNT1 (0.60) | CDK2CCNT1CDK9CDK1CDK4 | |
| SCHEMBL24418649 | 0.79 | CCNT1 (0.46) | CDK2CCNT1CDK9CDK1CDK4 | |
| SCHEMBL21946102 | 0.79 | CSNK2B (0.52) | CDK2CCNT1CDK9CDK1CDK4 | |
| SCHEMBL17980683 | 0.76 | GSK3B (0.47) | CDK2CCNT1CDK9CDK1CDK4 | |
| SCHEMBL15288758 | 0.76 | CDK2 (0.64) | CDK2CSNK2BCSNK2A1BCL6CSNK2A2 | |
| SCHEMBL30279964 | 0.76 | ALDH1A1 (0.45) | CDK2CCNT1CDK9CDK1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220002305-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CDK9 ACTIVITY | Kronos Bio, Inc. (US) | 2022-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220002305-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CDK9 ACTIVITY | CDK9, CDK19, CDK7 | CDK2 8/4885CCNT1 55/4885CDK9 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.