Sugi Predict

Sugi Predict / Compounds / SCHEMBL21947679

SCHEMBL21947679

SCHEMBL21947679

COc1ccc2c(C(=O)c3ccc(F)cc3)c(Cl)cnc2c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CCNC P24863 1/20 0.47
▸ CDK8 P49336 1/20 0.47
▸ PDE10A Q9Y233 2/20 0.47
▸ NQO2 P16083 1/20 0.43
▸ HPGDS O60760 2/20 0.42
▸ HTT P42858 2/20 0.42
▸ KDM4E B2RXH2 2/20 0.42
▸ ALDH1A1 P00352 3/20 0.42
▸ LMNA P02545 2/20 0.42
▸ HSP90AA1 P07900 1/20 0.42
▸ NPSR1 Q6W5P4 1/20 0.42
▸ MEN1 O00255 2/20 0.41
▸ KMT2A Q03164 2/20 0.41
▸ GAA P10253 1/20 0.41
▸ HPGD P15428 3/20 0.41
▸ MAPT P10636 3/20 0.41
▸ RAB9A P51151 2/20 0.41
▸ TRPA1 O75762 1/20 0.41
▸ RAF1 P04049 1/20 0.41
▸ MAPK1 P28482 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25332889 0.87 HPGDS (0.40) CCNCCDK8PDE10AHPGDSHTT
SCHEMBL30479234 0.87 HPGDS (0.40) CCNCCDK8PDE10AHPGDSHTT
SCHEMBL25967111 0.83 CYP8B1 (0.38) CCNCCDK8HPGDSHTTKDM4E
SCHEMBL25953849 0.82 CYP8B1 (0.38) CCNCCDK8HPGDSHTTKDM4E
SCHEMBL21947673 0.82 ESR1 (0.42) PDE10AHTTKDM4EMEN1KMT2A
SCHEMBL9662542 0.73 MAPT (0.68) HTTKDM4EALDH1A1LMNANPSR1
SCHEMBL25332124 0.73 SRC (0.45) HPGDSKDM4EALDH1A1HPGDF2
SCHEMBL20480283 0.72 SRC (0.47) NQO2HPGDSHTTKDM4EALDH1A1
SCHEMBL2313075 0.71 LMNA (0.56) KDM4EALDH1A1LMNANPSR1GAA
SCHEMBL21605339 0.70 LMNA (0.66) KDM4EALDH1A1LMNANPSR1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4472982-A1 PROCESSES FOR THE PREPARATION OF SELECTIVE ESTROGEN RECEPTOR DEGRADERS Eli Lilly and Company (US) 2024-12-11 — — EP disclosed
US-12128040-B2 Selective estrogen receptor degraders ELI LILLY AND COMPANY (US) 2024-10-29 — — US disclosed
CN-118647619-A Process for preparing selective estrogen receptor degrading agent 伊莱利利公司 2024-09-13 — — CN disclosed
US-20240199629-A1 PROCESSES FOR THE PREPARATION OF SELECTIVE ESTROGEN RECEPTOR DEGRADERS ELI LILLY AND COMPANY 2024-06-20 — — US disclosed
US-11993608-B2 Selective estrogen receptor degraders ELI LILLY AND COMPANY (US) 2024-05-28 — — US disclosed
US-11926634-B2 Processes for the preparation of selective estrogen receptor degraders ELI LILLY AND COMPANY (US) 2024-03-12 — — US disclosed
EP-4308581-A1 SELECTIVE ESTROGEN RECEPTOR DEGRADERS Eli Lilly and Company (US) 2024-01-24 — — EP disclosed
CN-117379428-A Selective estrogen receptor degrading agent 伊莱利利公司 2024-01-12 — — CN disclosed
CN-112424205-B Selective estrogen receptor degrading agents 伊莱利利公司 2023-10-31 — — CN disclosed
CN-116981679-A Selective estrogen receptor degrading agent 伊莱利利公司 2023-10-31 — — CN disclosed
US-11117902-B2 Selective estrogen receptor degraders ELI LILLY AND COMPANY (US) 2021-09-14 — — US disclosed
US-11117902-B2 Selective estrogen receptor degraders ELI LILLY AND COMPANY (US) 2021-09-14 — — US disclosed
EP-3820874-A1 SELECTIVE ESTROGEN RECEPTOR DEGRADERS Eli Lilly and Company (US) 2021-05-19 — — EP disclosed
EP-3820873-A1 SELECTIVE ESTROGEN RECEPTOR DEGRADERS Eli Lilly and Company (US) 2021-05-19 — — EP disclosed
CN-112638916-A Selective estrogen receptor degraders 伊莱利利公司 2021-04-09 — — CN disclosed
CN-112424205-A Selective estrogen receptor degraders 伊莱利利公司 2021-02-26 — — CN disclosed
US-20200347073-A1 SELECTIVE ESTROGEN RECEPTOR DEGRADERS ELI LILLY AND COMPANY 2020-11-05 — — US disclosed
US-20200347073-A1 SELECTIVE ESTROGEN RECEPTOR DEGRADERS ELI LILLY AND COMPANY 2020-11-05 — — US disclosed
US-10654866-B2 Selective estrogen receptor degraders ELI LILLY AND COMPANY (US) 2020-05-19 — — US disclosed
US-10654866-B2 Selective estrogen receptor degraders ELI LILLY AND COMPANY (US) 2020-05-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240199629-A1 PROCESSES FOR THE PREPARATION OF SELECTIVE ESTROGEN RECEPTOR DEGRADERS ESR1, GPER1, ESRRA CCNC 1360/4885CDK8 1111/4885PDE10A 1455/4885
US-11993608-B2 Selective estrogen receptor degraders ESR1, GPER1, ESR2 CCNC 1757/4885CDK8 927/4885PDE10A 2625/4885
US-20200347073-A1 SELECTIVE ESTROGEN RECEPTOR DEGRADERS ESR1, GPER1, ESR2 CCNC 1757/4885CDK8 927/4885PDE10A 2625/4885
US-11117902-B2 Selective estrogen receptor degraders ESR1, GPER1, ESR2 CCNC 1757/4885CDK8 927/4885PDE10A 2625/4885
US-11926634-B2 Processes for the preparation of selective estrogen receptor degraders ESR1, GPER1, ESRRA CCNC 1360/4885CDK8 1111/4885PDE10A 1455/4885
US-12128040-B2 Selective estrogen receptor degraders ESR1, GPER1, ESR2 CCNC 2566/4885CDK8 690/4885PDE10A 2533/4885
US-10654866-B2 Selective estrogen receptor degraders ESR1, GPER1, ESR2 CCNC 1757/4885CDK8 927/4885PDE10A 2625/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.