Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP8B1 | Q9UNU6 | 1/20 | 0.38 |
| ▸ | HPGDS | O60760 | 5/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.37 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25953849 | 0.85 | CYP8B1 (0.38) | CYP8B1HPGDSGABRA1GABRG2GABRB3 | |
| SCHEMBL25967134 | 0.84 | PDE4A (0.34) | CSF1R | |
| SCHEMBL21947679 | 0.83 | CCNC (0.47) | HPGDSALDH1A1F2GLAHPGD | |
| SCHEMBL25332889 | 0.81 | HPGDS (0.40) | CYP8B1HPGDSGABRA1GABRG2GABRB3 | |
| SCHEMBL30479234 | 0.81 | HPGDS (0.40) | CYP8B1HPGDSGABRA1GABRG2GABRB3 | |
| SCHEMBL25332124 | 0.77 | SRC (0.45) | HPGDSGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL20480283 | 0.71 | SRC (0.47) | HPGDSGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL25953862 | 0.70 | PDE4A (0.33) | CSF1R | |
| SCHEMBL2313075 | 0.70 | LMNA (0.56) | DHODHGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL2209879 | 0.69 | TRPA1 (0.47) | HPGDSGABRA1GABRG2GABRB3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023150056-A1 | PROCESSES FOR THE PREPARATION OF SELECTIVE ESTROGEN RECEPTOR DEGRADERS | ELI LILLY AND COMPANY (US) | 2023-08-10 | — | — | WO | disclosed |