Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | SIRT5 | Q9NXA8 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7828769 | 0.85 | SIRT5 (0.64) | MAPTSIRT5HPGDLMNAATM | |
| SCHEMBL5848968 | 0.77 | LMNA (0.75) | MAPTSIRT5HPGDLMNAATM | |
| SCHEMBL28653082 | 0.76 | PGK1 (0.49) | MAPTLMNAKMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL45134 | 0.75 | HRH3 (0.53) | MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL17807848 | 0.74 | EGFR (0.52) | MAPTSIRT5HPGDLMNAMEN1 | |
| SCHEMBL3997588 | 0.73 | MEN1 (0.45) | MAPTLMNAMEN1KMT2AL3MBTL1 | |
| SCHEMBL1182432 | 0.73 | SIRT5 (0.59) | MAPTSIRT5HPGDLMNAATM | |
| SCHEMBL45665 | 0.73 | MAPT (0.56) | MAPTLMNAL3MBTL1ALDH1A1 | |
| SCHEMBL20529668 | 0.72 | MAPT (0.42) | MAPTMEN1KMT2AALDH1A1GAA | |
| SCHEMBL6299408 | 0.72 | MEN1 (0.46) | MAPTMEN1KMT2AL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3271360-B1 | SUBSTITUTED TRICYCLIC HETEROCYCLIC COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2020-04-22 | — | — | EP | disclosed |