SCHEMBL2195258

SCHEMBL2195258

Clc1ccc(-c2nc3ccc(Cl)cn3c2Cn2nccn2)cc1

nearest known ligand 0.66

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SLC2A1 P11166 14/20 0.66
MEN1 O00255 1/20 0.66
KMT2A Q03164 1/20 0.66
KDM4E B2RXH2 1/20 0.63
HTT P42858 1/20 0.63
ALDH1A1 P00352 1/20 0.63
GABRA2 P47869 1/20 0.54
GABRB2 P47870 1/20 0.54
NR1I2 O75469 1/20 0.52
ABCB11 O95342 1/20 0.52
ALB P02768 1/20 0.52
ADORA3 P0DMS8 1/20 0.52
TSPO P30536 1/20 0.52
ADORA1 P30542 1/20 0.52
OPRM1 P35372 1/20 0.52
DRD3 P35462 1/20 0.52
OPRK1 P41145 1/20 0.52
PDE4D Q08499 1/20 0.52
KCNH2 Q12809 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2222798 0.92 SLC2A1 (0.61) SLC2A1MEN1KMT2AKDM4EHTT
SCHEMBL2195307 0.89 SLC2A3 (0.57) SLC2A1MEN1KMT2AKDM4EHTT
SCHEMBL1430221 0.83 KDM4E (0.67) SLC2A1KDM4EHTTGABRB2NR1I2
Hydrochloric Acid SCHEMBL1429987 0.81 ALDH1A1 (0.68) SLC2A1MEN1KMT2AKDM4EHTT
SCHEMBL1691241 0.81 ALDH1A1 (0.68) SLC2A1MEN1KMT2AKDM4EHTT
SCHEMBL1431433 0.80 SLC2A1 (0.59) SLC2A1MEN1KMT2AKDM4EHTT
SCHEMBL1431134 0.80 SLC2A1 (0.59) SLC2A1MEN1KMT2AKDM4EHTT
SCHEMBL2193875 0.80 GABRA1 (0.56) SLC2A1MEN1KMT2AKDM4EHTT
SCHEMBL1433352 0.80 SLC2A1 (0.65) SLC2A1MEN1KMT2AKDM4EHTT
SCHEMBL16261619 0.80 SLC2A1 (1.00) SLC2A1MEN1KMT2AKDM4EHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130289013-A1 IMIDAZO[1,2-a]PYRIDINE COMPOUNDS SUNOVION PHARMACEUTICALS INC. 2013-10-31 US disclosed
US-8497278-B2 Imidazo[1,2-a]pyridine compounds SUNOVION PHARMACEUTICALS INC. (US) 2013-07-30 US disclosed
US-20110166146-A1 IMIDAZO[1,2-a]PYRIDINE COMPOUNDS SUNOVION PHARMACEUTICALS INC. (US) 2011-07-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110166146-A1 IMIDAZO[1,2-a]PYRIDINE COMPOUNDS PAICS, ITPA, DPYD SLC2A1 2033/4885MEN1 1720/4885KMT2A 3191/4885
US-20130289013-A1 IMIDAZO[1,2-a]PYRIDINE COMPOUNDS PAICS, ITPA, DPYD SLC2A1 2033/4885MEN1 1720/4885KMT2A 3191/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.