Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 9/20 | 0.45 |
| ▸ | ICAM1 | P05362 | 9/20 | 0.45 |
| ▸ | ITGAL | P20701 | 9/20 | 0.45 |
| ▸ | ITGA4 | P13612 | 6/20 | 0.43 |
| ▸ | ITGB1 | P05556 | 4/20 | 0.40 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.35 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.35 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | ALB | P02768 | 1/20 | 0.35 |
| ▸ | IL2 | P60568 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21955081 | 1.00 | ITGB2 (0.45) | ITGB2ICAM1ITGALITGA4ITGB1 | |
| SCHEMBL22017695 | 0.91 | ITGB2 (0.36) | ITGB2ICAM1ITGALITGA4PSMB1 | |
| SCHEMBL21954964 | 0.89 | ITGB2 (0.42) | ITGB2ICAM1ITGALITGA4ITGB1 | |
| SCHEMBL21954965 | 0.89 | ITGB2 (0.42) | ITGB2ICAM1ITGALITGA4ITGB1 | |
| SCHEMBL21979129 | 0.85 | ITGB2 (0.55) | ITGB2ICAM1ITGALITGA4ITGB1 | |
| SCHEMBL21979127 | 0.85 | ITGB2 (0.55) | ITGB2ICAM1ITGALITGA4ITGB1 | |
| SCHEMBL21954944 | 0.80 | ITGB2 (0.52) | ITGB2ICAM1ITGALITGA4ITGB1 | |
| SCHEMBL21954943 | 0.80 | ITGB2 (0.52) | ITGB2ICAM1ITGALITGA4ITGB1 | |
| SCHEMBL22017367 | 0.80 | NLRP3 (0.35) | ITGB2ICAM1ITGALITGA4NPC1 | |
| SCHEMBL29736579 | 0.80 | NLRP3 (0.35) | ITGB2ICAM1ITGALITGA4NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220226337-A1 | COMPOUNDS FOR INHIBITION OF ALPHA 4 BETA 7 INTEGRIN | GILEAD SCIENCES, INC. | 2022-07-21 | — | — | US | disclosed |
| US-11224600-B2 | Compounds for inhibition of alpha 4 beta 7 integrin | GILEAD SCIENCES, INC. (US) | 2022-01-18 | — | — | US | disclosed |
| EP-3873897-A1 | COMPOUNDS FOR INHIBITION OF ALPHA 4 BETA 7 INTEGRIN | GILEAD SCIENCES, INC. (US) | 2021-09-08 | — | — | EP | disclosed |
| US-20200155563-A1 | COMPOUNDS FOR INHIBITION OF ALPHA 4 BETA 7 INTEGRIN | GILEAD SCIENCES, INC. | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220226337-A1 | COMPOUNDS FOR INHIBITION OF ALPHA 4 BETA 7 INTEGRIN | ITGB7, ITGB4, ITGA4 | ITGB2 5/4885ICAM1 32/4885ITGAL 6/4885 |
| US-20200155563-A1 | COMPOUNDS FOR INHIBITION OF ALPHA 4 BETA 7 INTEGRIN | ITGB7, ITGB4, ITGA4 | ITGB2 5/4885ICAM1 32/4885ITGAL 6/4885 |
| US-11224600-B2 | Compounds for inhibition of alpha 4 beta 7 integrin | ITGB7, ITGB4, ITGA4 | ITGB2 5/4885ICAM1 32/4885ITGAL 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.