Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGA4 | P13612 | 9/20 | 0.33 |
| ▸ | ITGB1 | P05556 | 7/20 | 0.32 |
| ▸ | ITGB7 | P26010 | 5/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | MMP3 | P08254 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.31 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.30 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.30 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.30 |
| ▸ | ITGAL | P20701 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21955164 | 1.00 | ITGA4 (0.33) | ITGA4ITGB1ITGB7MMP1MMP3 | |
| SCHEMBL21955169 | 1.00 | ITGA4 (0.33) | ITGA4ITGB1ITGB7MMP1MMP3 | |
| SCHEMBL22016564 | 0.94 | CNR2 (0.35) | NPSR1 | |
| SCHEMBL22016857 | 0.92 | ROCK2 (0.31) | — | |
| SCHEMBL21955284 | 0.90 | ITGA4 (0.31) | ITGA4ITGB1ITGB7NPSR1 | |
| SCHEMBL21955281 | 0.90 | ITGA4 (0.31) | ITGA4ITGB1ITGB7NPSR1 | |
| SCHEMBL21955283 | 0.90 | ITGA4 (0.31) | ITGA4ITGB1ITGB7NPSR1 | |
| SCHEMBL22017195 | 0.89 | ROCK2 (0.30) | ITGA4ITGB1 | |
| SCHEMBL21957250 | 0.88 | ITGB1 (0.33) | ITGA4ITGB1MAPK1PIK3C3ITGB2 | |
| SCHEMBL21957252 | 0.88 | ITGB1 (0.33) | ITGA4ITGB1MAPK1PIK3C3ITGB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220226337-A1 | COMPOUNDS FOR INHIBITION OF ALPHA 4 BETA 7 INTEGRIN | GILEAD SCIENCES, INC. | 2022-07-21 | — | — | US | disclosed |
| US-11224600-B2 | Compounds for inhibition of alpha 4 beta 7 integrin | GILEAD SCIENCES, INC. (US) | 2022-01-18 | — | — | US | disclosed |
| CN-112996786-A | Compounds for inhibiting alpha 4 beta 7 integrins | 吉利德科学公司 | 2021-06-18 | — | — | CN | disclosed |
| US-20200155563-A1 | COMPOUNDS FOR INHIBITION OF ALPHA 4 BETA 7 INTEGRIN | GILEAD SCIENCES, INC. | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220226337-A1 | COMPOUNDS FOR INHIBITION OF ALPHA 4 BETA 7 INTEGRIN | ITGB7, ITGB4, ITGA4 | ITGA4 3/4885ITGB1 4/4885ITGB7 1/4885 |
| US-20200155563-A1 | COMPOUNDS FOR INHIBITION OF ALPHA 4 BETA 7 INTEGRIN | ITGB7, ITGB4, ITGA4 | ITGA4 3/4885ITGB1 4/4885ITGB7 1/4885 |
| US-11224600-B2 | Compounds for inhibition of alpha 4 beta 7 integrin | ITGB7, ITGB4, ITGA4 | ITGA4 3/4885ITGB1 4/4885ITGB7 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.