SCHEMBL2195535

SCHEMBL2195535

N=C(N)NCCC[C@@H]([C]=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1

nearest known ligand 0.53

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ GHSR Q92847 5/20 0.53
▸ KISS1R Q969F8 6/20 0.47
▸ MC4R P32245 3/20 0.44
▸ PRKACB P22694 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2197058 1.00 GHSR (0.53) GHSRKISS1RMC4RPRKACB
SCHEMBL31001649 0.91 GHSR (0.57) GHSRKISS1RMC4R
SCHEMBL31606511 0.88 GHSR (0.59) GHSRKISS1RMC4R
SCHEMBL30866241 0.88 GHSR (0.62) GHSRKISS1RPRKACB
SCHEMBL21570983 0.88 GHSR (0.64) GHSRKISS1RMC4RPRKACB
SCHEMBL21570985 0.88 GHSR (0.64) GHSRKISS1RMC4RPRKACB
SCHEMBL21570979 0.88 GHSR (0.64) GHSRKISS1RMC4RPRKACB
SCHEMBL31026129 0.87 GHSR (0.60) GHSRKISS1R
SCHEMBL30866231 0.87 GHSR (0.57) GHSRKISS1RMC4R
SCHEMBL29895432 0.87 GHSR (0.53) GHSR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9173951-B2 Carbohydrate-based drug delivery polymers and conjugates thereof NEKTAR THERAPEUTICS (US) 2015-11-03 — — US disclosed
US-20150051371-A1 CARBOHYDRATE-BASED DRUG DELIVERY POLYMERS AND CONJUGATES THEREOF NEKTAR THERAPEUTICS (US) 2015-02-19 — — US disclosed
US-8680263-B2 Carbohydrate-based drug delivery polymers and conjugates thereof NEKTAR THERAPEUTICS (US) 2014-03-25 — — US disclosed
US-20110171716-A1 CARBOHYDRATE-BASED DRUG DELIVERY POLYMERS AND CONJUGATES THEREOF NEKTAR THERAPEUTICS (US) 2011-07-14 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110171716-A1 CARBOHYDRATE-BASED DRUG DELIVERY POLYMERS AND CONJUGATES THEREOF STT3B, STT3A, DDOST GHSR 1832/4885KISS1R 3907/4885MC4R 1805/4885
US-20150051371-A1 CARBOHYDRATE-BASED DRUG DELIVERY POLYMERS AND CONJUGATES THEREOF STT3B, STT3A, DDOST GHSR 1832/4885KISS1R 3907/4885MC4R 1805/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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