Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | PDE9A | O76083 | 4/20 | 0.35 |
| ▸ | PDE1C | Q14123 | 8/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 8/20 | 0.34 |
| ▸ | PDE1A | P54750 | 7/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20674179 | 0.78 | AURKA (0.35) | GRM1ALDH1A1HSD17B10PDE9APDE1C | |
| SCHEMBL23937730 | 0.77 | MEN1 (0.35) | GRM1ALDH1A1 | |
| SCHEMBL23937738 | 0.74 | GPR119 (0.39) | PDE9APDE1CPDE1BPDE1AGPR119 | |
| SCHEMBL23937883 | 0.73 | GRM1 (0.40) | GRM1AURKA | |
| SCHEMBL21848992 | 0.72 | DRD2 (0.38) | ALDH1A1CYP1A2MAPK1CASP1CASP7 | |
| SCHEMBL22789246 | 0.67 | CNR2 (0.35) | PDE9APDE1CPDE1BPDE1AGPR119 | |
| SCHEMBL20282648 | 0.65 | AURKA (0.35) | ALDH1A1PDE9APDE1CGPR119AURKA | |
| SCHEMBL27402945 | 0.65 | HDAC8 (0.38) | HSD17B10AURKACDK1AURKBCCND1 | |
| SCHEMBL20674182 | 0.65 | CNR2 (0.35) | GRM1PDE9AAURKACDK1AURKB | |
| SCHEMBL21871188 | 0.65 | GPR119 (0.49) | CYP1A2PDE9APDE1CPDE1BPDE1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3399968-B1 | SELECTIVE INHIBITORS OF CLINICALLY IMPORTANT MUTANTS OF THE EGFR TYROSINE KINASE | CS PHARMATECH LTD (KY) | 2021-10-20 | — | — | EP | disclosed |
| US-20200131176-A1 | SELECTIVE INHIBITORS OF CLINICALLY IMPORTANT MUTANTS OF THE EGFR TYROSINE KINASE | CS PHARMATECH LIMITED (KY) | 2020-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200131176-A1 | SELECTIVE INHIBITORS OF CLINICALLY IMPORTANT MUTANTS OF THE EGFR TYROSINE KINASE | EGFR, ERBB3, ERBB2 | GRM1 2987/4885ALDH1A1 3098/4885CYP1A2 2316/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.