Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | PHGDH | O43175 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.43 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.43 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.43 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | IDH2 | P48735 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21959807 | 0.93 | IDH2 (0.47) | EPHX2PHGDHKMT2AMALT1MEN1 | |
| SCHEMBL21958711 | 0.87 | MALT1 (0.46) | EPHX2LMNAKMT2ARAB9AMALT1 | |
| SCHEMBL21856302 | 0.82 | EPHX2 (0.45) | EPHX2LMNAPHGDHKMT2ARAB9A | |
| SCHEMBL21856323 | 0.82 | IDH2 (0.45) | EPHX2PHGDHKMT2AMALT1MEN1 | |
| SCHEMBL21958162 | 0.81 | TEAD1 (0.61) | EPHX2PHGDHKMT2ARAB9AMEN1 | |
| SCHEMBL21856330 | 0.80 | ROCK2 (0.52) | EPHX2LMNAPHGDHKMT2AMEN1 | |
| SCHEMBL12076535 | 0.80 | EPHX2 (0.63) | EPHX2LMNAKMT2ARAB9AMALT1 | |
| SCHEMBL19101438 | 0.79 | PHGDH (0.52) | EPHX2LMNAPHGDHKMT2AMALT1 | |
| SCHEMBL15120074 | 0.79 | PHGDH (0.54) | EPHX2LMNAPHGDHKMT2AMALT1 | |
| SCHEMBL21856338 | 0.78 | PHGDH (0.46) | EPHX2LMNAPHGDHKMT2AMALT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081572-A1 | TRANSCRIPTIONAL ENHANCED ASSOCIATE DOMAIN (TEAD) TRANSCRIPTION FACTOR INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-04-23 | — | — | WO | disclosed |