Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 4/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PHGDH | O43175 | 2/20 | 0.47 |
| ▸ | CCR2 | P41597 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | UBE2M | P61081 | 1/20 | 0.44 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MLNR | O43193 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21856366 | 0.82 | DCUN1D1 (0.49) | ROCK2KMT2AMEN1UBE2MDCUN1D1 | |
| SCHEMBL21959809 | 0.80 | EPHX2 (0.50) | ROCK2GAAPHGDHKMT2AEPHX2 | |
| SCHEMBL19101438 | 0.78 | PHGDH (0.52) | ROCK2PHGDHKMT2AEPHX2MEN1 | |
| SCHEMBL15120074 | 0.78 | PHGDH (0.54) | ROCK2PHGDHKMT2AEPHX2LMNA | |
| SCHEMBL21958173 | 0.78 | KMT2A (0.62) | PHGDHCCR2KCNH2KMT2AEPHX2 | |
| SCHEMBL21958193 | 0.78 | KMT2A (0.62) | PHGDHCCR2KCNH2KMT2AEPHX2 | |
| SCHEMBL21856338 | 0.78 | PHGDH (0.46) | ROCK2PHGDHCCR2KCNH2KMT2A | |
| SCHEMBL21856333 | 0.78 | PHGDH (0.46) | ROCK2PHGDHCCR2KCNH2KMT2A | |
| SCHEMBL21856359 | 0.78 | PHGDH (0.46) | ROCK2PHGDHCCR2KCNH2KMT2A | |
| SCHEMBL11577402 | 0.77 | UBE2M (0.63) | ROCK2PHGDHKMT2AEPHX2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081572-A1 | TRANSCRIPTIONAL ENHANCED ASSOCIATE DOMAIN (TEAD) TRANSCRIPTION FACTOR INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-04-23 | — | — | WO | disclosed |