Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 12/20 | 0.44 |
| ▸ | RET | P07949 | 6/20 | 0.41 |
| ▸ | KDR | P35968 | 5/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21960344 | 0.77 | PDE7A (0.43) | PDE7ARETKDR | |
| SCHEMBL21960901 | 0.77 | KDM4E (0.41) | PDE7APIK3CDMAP3K14 | |
| SCHEMBL22424005 | 0.73 | BAZ2B (0.47) | — | |
| SCHEMBL26416280 | 0.72 | PKM (0.47) | PDE7APIK3CD | |
| SCHEMBL31052495 | 0.71 | HPGD (0.43) | PDE7AKDRPIK3CD | |
| SCHEMBL20489182 | 0.71 | BRD4 (0.45) | PDE7A | |
| SCHEMBL21960851 | 0.70 | MAP3K14 (0.39) | MAP3K14 | |
| SCHEMBL25083966 | 0.70 | KMT2A (0.44) | PDE7APIK3CD | |
| SCHEMBL21960888 | 0.70 | BAZ2B (0.39) | PDE7ARETKDRMAP3K14 | |
| SCHEMBL10282157 | 0.69 | HPGD (0.45) | PDE7A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11136311-B2 | Heteroaromatic derivatives as NIK inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2021-10-05 | — | — | US | disclosed |
| EP-3478675-B1 | HETEROAROMATIC DERIVATIVES AS NIK INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-04-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11136311-B2 | Heteroaromatic derivatives as NIK inhibitors | NFKBIA, IKBKG, IKBKE | PDE7A 2625/4885RET 1416/4885KDR 2851/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.