Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | L3MBTL3 | Q96JM7 | 8/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 8/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MBTD1 | Q05BQ5 | 2/20 | 0.36 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.36 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.36 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21960919 | 0.80 | L3MBTL3 (0.38) | KDM4EL3MBTL3L3MBTL1ALDH1A1NPC1 | |
| SCHEMBL21960936 | 0.78 | PKM (0.40) | L3MBTL3L3MBTL1ALDH1A1KMT2AMEN1 | |
| SCHEMBL21960357 | 0.77 | PDE7A (0.44) | PIK3CDPDE7AMAP3K14 | |
| SCHEMBL14912522 | 0.75 | KDM4E (0.46) | KDM4EHSD11B1ALDH1A1NPC1RAB9A | |
| SCHEMBL31052495 | 0.67 | HPGD (0.43) | KDM4EPIK3CDPDE7AALDH1A1NPC1 | |
| SCHEMBL10282157 | 0.66 | HPGD (0.45) | KDM4EPDE7AALDH1A1NPC1RAB9A | |
| SCHEMBL31612962 | 0.64 | NR3C2 (0.35) | KDM4EPIK3CDALDH1A1 | |
| SCHEMBL14912963 | 0.63 | SMN1; SMN2 (0.47) | KDM4EL3MBTL1NPC1RAB9A | |
| SCHEMBL25400204 | 0.63 | KCNJ3 (0.45) | KDM4EALDH1A1 | |
| SCHEMBL26643742 | 0.63 | HCAR3 (0.41) | PDE7A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11136311-B2 | Heteroaromatic derivatives as NIK inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2021-10-05 | — | — | US | disclosed |
| EP-3478675-B1 | HETEROAROMATIC DERIVATIVES AS NIK INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-04-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11136311-B2 | Heteroaromatic derivatives as NIK inhibitors | NFKBIA, IKBKG, IKBKE | KDM4E 2358/4885L3MBTL3 2658/4885L3MBTL1 2728/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.