Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | AHR | P35869 | 3/20 | 0.40 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | PRKCI | P41743 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TYMS | P04818 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31511760 | 1.00 | PBRM1 (0.41) | PBRM1CASP1CASP7HSD17B10AHR | |
| SCHEMBL29914436 | 0.92 | PBRM1 (0.41) | PBRM1CASP1CASP7HSD17B10AHR | |
| SCHEMBL19887446 | 0.92 | PBRM1 (0.41) | PBRM1CASP1CASP7HSD17B10AHR | |
| SCHEMBL23051659 | 0.83 | PBRM1 (0.47) | PBRM1CASP1CASP7HSD17B10HSD17B1 | |
| SCHEMBL1512735 | 0.83 | PBRM1 (0.47) | PBRM1CASP1CASP7HSD17B10AHR | |
| SCHEMBL31591225 | 0.83 | PBRM1 (0.47) | PBRM1CASP1CASP7HSD17B10AHR | |
| SCHEMBL31591224 | 0.83 | PBRM1 (0.47) | PBRM1CASP1CASP7HSD17B10HSD17B1 | |
| SCHEMBL15689674 | 0.81 | MAOA (0.49) | HSD17B1MEN1KMT2AMAOAMAOB | |
| SCHEMBL2907226 | 0.76 | PBRM1 (0.41) | PBRM1CASP1CASP7HSD17B10HSD17B1 | |
| SCHEMBL6206980 | 0.76 | CASP1 (0.50) | PBRM1CASP1CASP7HSD17B10HSD17B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3880685-A2 | INHIBITORS OF ARG1 AND/OR ARG2 | Arcus Biosciences, Inc. (US) | 2021-09-22 | — | — | EP | disclosed |
| WO-2020102646-A2 | INHIBITORS OF ARG1 AND/OR ARG2 | ARCUS BIOSCIENCES, INC. (US) | 2020-05-22 | — | — | WO | disclosed |
| WO-2020102646-A2 | INHIBITORS OF ARG1 AND/OR ARG2 | ARCUS BIOSCIENCES, INC. (US) | 2020-05-22 | — | — | WO | disclosed |