Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.41 |
| ▸ | TYMS | P04818 | 2/20 | 0.40 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | PRKCI | P41743 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1512735 | 0.83 | PBRM1 (0.47) | CASP1CASP7HSD17B10PBRM1TYMS | |
| SCHEMBL31591225 | 0.83 | PBRM1 (0.47) | CASP1CASP7HSD17B10PBRM1TYMS | |
| SCHEMBL460543 | 0.83 | CASP1 (0.57) | CASP1CASP7HSD17B10PBRM1TYMS | |
| SCHEMBL31511760 | 0.76 | PBRM1 (0.41) | CASP1CASP7HSD17B10PBRM1TYMS | |
| SCHEMBL21962019 | 0.76 | PBRM1 (0.41) | CASP1CASP7HSD17B10PBRM1TYMS | |
| SCHEMBL2300153 | 0.76 | CASP7 (0.50) | CASP1CASP7HSD17B10PBRM1TYMS | |
| SCHEMBL29618363 | 0.76 | CASP7 (0.50) | CASP1CASP7HSD17B10PBRM1TYMS | |
| SCHEMBL2907226 | 0.76 | PBRM1 (0.41) | CASP1CASP7HSD17B10PBRM1TYMS | |
| SCHEMBL7888335 | 0.76 | CASP1 (0.50) | CASP1CASP7HSD17B10PBRM1HSD17B1 | |
| SCHEMBL1025098 | 0.76 | HSD17B10 (0.50) | CASP1CASP7HSD17B10PBRM1TYMS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109956928-B | Pyridine compound, preparation method and application thereof | 四川科伦博泰生物医药股份有限公司 | 2021-07-09 | — | — | CN | disclosed |
| EP-1603887-B1 | HIV REPLICATION INHIBITING INDANE SUBSTITUTED PYRIMIDINES | TIBOTEC PHARM LTD (IE) | 2011-04-20 | — | — | EP | disclosed |
| US-7585870-B2 | HIV replication inhibiting pyrimidines and triazines | TIBOTEC BVBA (BE) | 2009-09-08 | — | — | US | disclosed |
| US-7585870-B2 | HIV replication inhibiting pyrimidines and triazines | TIBOTEC BVBA (BE) | 2009-09-08 | — | — | US | disclosed |
| US-7442705-B2 | HIV replication inhibiting pyrimidines and triazines | TIBOTEC PHARMACEUTICALS LTD (IE) | 2008-10-28 | — | — | US | disclosed |
| US-7442705-B2 | HIV replication inhibiting pyrimidines and triazines | TIBOTEC PHARMACEUTICALS LTD (IE) | 2008-10-28 | — | — | US | disclosed |
| EP-1597238-B1 | HIV REPLICATION INHIBITING PYRIMIDINES AND TRIAZINES | TIBOTEC PHARM LTD (IE) | 2007-05-09 | — | — | EP | disclosed |
| EP-1098891-B1 | POLYCYCLIC THIAZOLIDIN-2-YLIDENE AMINES, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | AVENTIS PHARMA GMBH (DE) | 2005-08-10 | — | — | EP | disclosed |
| EP-1098891-A1 | POLYCYCLIC THIAZOLIDIN-2-YLIDENE AMINES, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | Aventis Pharma Deutschland GmbH (DE) | 2001-05-16 | — | — | EP | disclosed |
| US-6159996-A | Polycyclic thiazolidin-2-ylidene amines, process for their preparation, and their use as pharmaceuticals | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-12-12 | — | — | US | disclosed |
| WO-2000004006-A1 | POLYCYCLIC THIAZOLIDIN-2-YLIDENE AMINES, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-01-27 | — | — | WO | disclosed |
| US-4129656-A | Thiazolidine derivatives, salidiuretic compositions and methods of effecting salidiuresis employing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1978-12-12 | — | — | US | disclosed |