Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | PTP4A3 | O75365 | 1/20 | 0.38 |
| ▸ | PTP4A2 | Q12974 | 1/20 | 0.38 |
| ▸ | PTP4A1 | Q93096 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 3/20 | 0.37 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4515919 | 0.84 | RAB9A (0.55) | RAB9ALMNAKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL14911794 | 0.81 | GSK3B (0.56) | RAB9ALMNAALDH1A1HPGDMAPT | |
| SCHEMBL386804 | 0.75 | RAB9A (0.49) | RAB9ALMNAKDM4ESMN1; SMN2CYP1A1 | |
| SCHEMBL21963437 | 0.74 | ELANE (0.42) | RAB9ASMN1; SMN2ALDH1A1HPGDMAPT | |
| SCHEMBL7835046 | 0.71 | PARP1 (0.39) | RAB9ALMNAKDM4ECYP1A2CHEK1 | |
| SCHEMBL1774094 | 0.69 | PARP1 (0.43) | RAB9ALMNAKDM4ECYP1A2CHEK1 | |
| SCHEMBL4341520 | 0.69 | ALDH1A1 (0.47) | RAB9ALMNAKDM4ECYP1A2CHEK1 | |
| SCHEMBL6226394 | 0.69 | CHEK1 (0.50) | CHEK1ALDH1A1PARP1IKBKB | |
| SCHEMBL15716637 | 0.67 | CYP2A6 (0.42) | RAB9ALMNAKDM4ECYP1A2CHEK1 | |
| SCHEMBL5849531 | 0.66 | TMIGD3 (0.51) | RAB9ALMNAKDM4ESMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3880200-A2 | IN-FLOW PHOTOOXYGENATION OF AMINOTHIENOPYRIDINONES GENERATES NOVEL PTP4A3 PHOSPHATASE INHIBITORS | University of Virginia Patent Foundation (US) | 2021-09-22 | — | — | EP | disclosed |
| EP-3880684-A1 | IN-FLOW PHOTOOXYGENATION OF AMINOTHIENOPYRIDINONES GENERATES NOVEL PTP4A3 PHOSPHATASE INHIBITORS | University of Virginia Patent Foundation (US) | 2021-09-22 | — | — | EP | disclosed |
| WO-2020102243-A2 | IN-FLOW PHOTOOXYGENATION OF AMINOTHIENOPYRIDINONES GENERATES NOVEL PTP4A3 PHOSPHATASE INHIBITORS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2020-05-22 | — | — | WO | disclosed |
| WO-2020102245-A1 | IN-FLOW PHOTOOXYGENATION OF AMINOTHIENOPYRIDINONES GENERATES NOVEL PTP4A3 PHOSPHATASE INHIBITORS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2020-05-22 | — | — | WO | disclosed |