Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.47 |
| ▸ | ADCY10 | Q96PN6 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22849597 | 0.82 | SIGMAR1 (0.46) | SIGMAR1ADCY10NPC1ALDH1A1KDM4E | |
| SCHEMBL24158999 | 0.81 | SIGMAR1 (0.47) | SIGMAR1ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL21570189 | 0.80 | MEN1 (0.50) | SIGMAR1NPC1ALDH1A1KDM4EMEN1 | |
| SCHEMBL21960997 | 0.80 | SIGMAR1 (0.45) | SIGMAR1NPC1ALDH1A1KDM4EMEN1 | |
| SCHEMBL21960999 | 0.79 | SIGMAR1 (0.44) | SIGMAR1NPC1ALDH1A1KDM4EMEN1 | |
| SCHEMBL21570271 | 0.76 | SMN1; SMN2 (0.49) | SIGMAR1ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL14334527 | 0.74 | GRM4 (0.53) | NPC1ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL27087768 | 0.74 | TSHR (0.40) | SIGMAR1ALDH1A1KDM4ESYKTSHR | |
| SCHEMBL31714258 | 0.73 | LMNA (0.38) | ALDH1A1LMNA | |
| SCHEMBL5115745 | 0.73 | PDPK1 (0.46) | SIGMAR1ALDH1A1MEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11136311-B2 | Heteroaromatic derivatives as NIK inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2021-10-05 | — | — | US | disclosed |
| EP-3478675-B1 | HETEROAROMATIC DERIVATIVES AS NIK INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-04-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11136311-B2 | Heteroaromatic derivatives as NIK inhibitors | NFKBIA, IKBKG, IKBKE | SIGMAR1 3838/4885ADCY10 3732/4885NPC1 1362/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.