Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 3/20 | 0.32 |
| ▸ | CDK4 | P11802 | 3/20 | 0.32 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.32 |
| ▸ | CCND1 | P24385 | 3/20 | 0.32 |
| ▸ | CDK2 | P24941 | 3/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.31 |
| ▸ | CCND3 | P30281 | 1/20 | 0.31 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20331523 | 0.83 | PDPK1 (0.34) | CDK1CDK4CCNB1CCNA2CCND1 | |
| SCHEMBL21964551 | 0.78 | CDK1 (0.33) | CDK1CDK4CCNB1CCNA2CCND1 | |
| SCHEMBL13145006 | 0.71 | — | — | |
| SCHEMBL10269956 | 0.69 | — | — | |
| SCHEMBL9971597 | 0.67 | KDM4E (0.30) | — | |
| SCHEMBL20755836 | 0.64 | CDC7 (0.43) | CCNA2CDK2CCNA1 | |
| SCHEMBL13461658 | 0.64 | TRPA1 (0.33) | CDK1CDK4CCNB1CCNA2CCND1 | |
| SCHEMBL19845914 | 0.64 | TRPA1 (0.33) | CDK1CDK4CCNB1CCNA2CCND1 | |
| SCHEMBL19497951 | 0.61 | CDK2 (0.33) | CDK2CCNA1 | |
| SCHEMBL21961391 | 0.61 | HPGDS (0.44) | CDK1CDK4CCNB1CCNA2CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3478675-B1 | HETEROAROMATIC DERIVATIVES AS NIK INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-04-22 | — | — | EP | disclosed |