Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NOS1 | P29475 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18418892 | 0.78 | SMN1; SMN2 (0.53) | ALDH1A1SMN1; SMN2NOS1MAPTCYP3A4 | |
| SCHEMBL971909 | 0.77 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2NOS1MAPTCYP3A4 | |
| SCHEMBL15528272 | 0.74 | SMN1; SMN2 (0.49) | ALDH1A1SMN1; SMN2NOS1MAPTCYP3A4 | |
| SCHEMBL9357312 | 0.74 | SMN1; SMN2 (0.49) | ALDH1A1SMN1; SMN2NOS1MAPTCYP3A4 | |
| SCHEMBL2549735 | 0.74 | SMN1; SMN2 (0.49) | ALDH1A1SMN1; SMN2NOS1MAPTCYP3A4 | |
| SCHEMBL27895476 | 0.73 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2NOS1MAPTCYP3A4 | |
| SCHEMBL28758091 | 0.72 | SMN1; SMN2 (0.44) | ALDH1A1SMN1; SMN2NOS1MAPTCYP3A4 | |
| SCHEMBL9355658 | 0.71 | SMN1; SMN2 (0.42) | ALDH1A1SMN1; SMN2NOS1MAPTCYP3A4 | |
| SCHEMBL5021113 | 0.70 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2NOS1MAPTCYP3A4 | |
| SCHEMBL28033273 | 0.69 | NPC1 (0.35) | ALDH1A1NOS1MAPTCYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11136311-B2 | Heteroaromatic derivatives as NIK inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2021-10-05 | — | — | US | disclosed |
| EP-3478675-B1 | HETEROAROMATIC DERIVATIVES AS NIK INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-04-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11136311-B2 | Heteroaromatic derivatives as NIK inhibitors | NFKBIA, IKBKG, IKBKE | ALDH1A1 3872/4885SMN1; SMN2 4338/4885NOS1 872/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.