Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | TACR3 | P29371 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL160276 | 0.75 | SMN1; SMN2 (0.51) | ALPL | |
| SCHEMBL12332643 | 0.74 | SMN1; SMN2 (0.37) | MAPTPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL175136 | 0.74 | SMN1; SMN2 (0.40) | MAPTALDH1A1KMT2A | |
| SCHEMBL21964601 | 0.72 | ALPL (0.49) | ALPLMAPTALDH1A1HPGDTACR3 | |
| SCHEMBL28876776 | 0.71 | ALDH1A1 (0.45) | MAPTPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL16524045 | 0.70 | SMN1; SMN2 (0.37) | MAPTPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL627520 | 0.70 | MAPK1 (0.57) | ALPLMAPTPOLBNPC1 | |
| SCHEMBL3455486 | 0.70 | ALPL (0.49) | ALPLPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL13148139 | 0.69 | CSF1R (0.66) | MAPTPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL3932634 | 0.69 | MAPK8 (0.55) | MAPTPOLBALDH1A1HPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3478675-B1 | HETEROAROMATIC DERIVATIVES AS NIK INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-04-22 | — | — | EP | disclosed |