Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 8/20 | 0.49 |
| ▸ | TACR3 | P29371 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12304379 | 0.73 | TP53 (0.47) | ALPLTP53 | |
| SCHEMBL14235380 | 0.73 | ALPL (0.48) | ALPLTACR3HPGDNPC1RAB9A | |
| SCHEMBL3455486 | 0.72 | ALPL (0.49) | ALPLTACR3HPGDALDH1A1HRH4 | |
| SCHEMBL21964602 | 0.72 | ALPL (0.47) | ALPLTACR3HPGDALDH1A1NPC1 | |
| SCHEMBL28511427 | 0.71 | TACR3 (0.76) | ALPLTACR3ALDH1A1KDM5BMAPT | |
| SCHEMBL12304381 | 0.68 | MAPK1 (0.61) | ALPLNPC1RAB9AMAPTLMNA | |
| SCHEMBL28905677 | 0.66 | L3MBTL1 (0.67) | ALPLTACR3ALDH1A1NPC1RAB9A | |
| SCHEMBL30699799 | 0.66 | HPGD (0.42) | ALPLHPGDALDH1A1HRH4HRH3 | |
| SCHEMBL8001697 | 0.64 | ALPL (0.54) | ALPLTACR3HPGDALDH1A1NPC1 | |
| SCHEMBL21960919 | 0.63 | L3MBTL3 (0.38) | HPGDALDH1A1NPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3478675-B1 | HETEROAROMATIC DERIVATIVES AS NIK INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-04-22 | — | — | EP | disclosed |