Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 7/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | TSHR | P16473 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | BLM | P54132 | 4/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2200379 | 0.86 | ADRB2 (0.44) | ADRB2KDM4ETSHRLMNABLM | |
| SCHEMBL2198620 | 0.86 | ADRB2 (0.44) | ADRB2KDM4ETSHRLMNABLM | |
| SCHEMBL2197814 | 0.83 | KDM4E (0.57) | ADRB2KDM4ELMNACYP1A2ADRB3 | |
| SCHEMBL2199004 | 0.83 | BCHE (0.47) | ADRB2ADRB1ADRB3 | |
| SCHEMBL2197422 | 0.83 | BCHE (0.47) | ADRB2ADRB1ADRB3 | |
| SCHEMBL2196410 | 0.82 | RIPK1 (0.37) | KDM4ETSHRLMNAMEN1KMT2A | |
| SCHEMBL2195384 | 0.82 | RIPK1 (0.37) | KDM4ETSHRLMNAMEN1KMT2A | |
| SCHEMBL2200003 | 0.81 | KMT2A (0.39) | ADRB2KDM4EMAPTTSHRLMNA | |
| SCHEMBL2197629 | 0.80 | KDM4E (0.43) | KDM4EMAPTMEN1KMT2AMAPK1 | |
| SCHEMBL2199143 | 0.80 | KMT2A (0.38) | ADRB2KDM4EMAPTTSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977336-B2 | Aminopyrimidine derivatives as PLK1 inhibitors | BANYU PHARMACEUTICAL CO. LTD (JP) | 2011-07-12 | — | — | US | disclosed |