Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.45 |
| ▸ | USP1 | O94782 | 1/20 | 0.45 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 2/20 | 0.44 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.44 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2198386 | 0.94 | PDE5A (0.53) | PDE5AKMT2AALDH1A1HPGDNPSR1 | |
| SCHEMBL2198240 | 0.90 | ALDH1A1 (0.54) | PDE5AKMT2AALDH1A1HPGDNPSR1 | |
| SCHEMBL2198508 | 0.88 | BRD4 (0.46) | PDE5AKMT2AALDH1A1HPGDNPSR1 | |
| SCHEMBL2198123 | 0.82 | HPGD (0.54) | PDE5AKMT2AALDH1A1HPGDNPSR1 | |
| SCHEMBL2196171 | 0.82 | EPHX2 (0.50) | PDE5AALDH1A1CLK4EPHX2 | |
| SCHEMBL2199244 | 0.82 | GAA (0.47) | PDE5AKMT2AEPHX2GAABRD4 | |
| SCHEMBL2196713 | 0.82 | BRD4 (0.46) | PDE5AKMT2AALDH1A1CLK4GAA | |
| SCHEMBL2197915 | 0.82 | CLK4 (0.52) | KMT2AALDH1A1HPGDCLK4EPHX2 | |
| SCHEMBL2199265 | 0.80 | CLK4 (0.51) | KMT2AALDH1A1HPGDCLK4MEN1 | |
| SCHEMBL2194237 | 0.80 | CYP1A2 (0.53) | PDE5AKMT2AALDH1A1HPGDNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977360-B2 | Benzo[d]isoxazol-3-yl-amine compounds and their use as vanilloid receptor ligands | GRUENENTHAL GMBH (DE) | 2011-07-12 | — | — | US | claimed |
| EP-1888541-B1 | BENZO(D)ISOXAZOL-3-YL-AMINE COMPOUNDS AND THEIR USE AS VANILLOID RECEPTOR LIGANDS | GRUENENTHAL GMBH (DE) | 2009-08-05 | — | — | EP | claimed |
| US-20090042945-A1 | Benzo[d]isoxazol-3-yl-amine Compounds and Their Use as Vanilloid Receptor Ligands | GRUENENTHAL GMBH (DE) | 2009-02-12 | — | — | US | claimed |
| US-7977360-B2 | Benzo[d]isoxazol-3-yl-amine compounds and their use as vanilloid receptor ligands | GRUENENTHAL GMBH (DE) | 2011-07-12 | — | — | US | disclosed |
| EP-1888541-B1 | BENZO(D)ISOXAZOL-3-YL-AMINE COMPOUNDS AND THEIR USE AS VANILLOID RECEPTOR LIGANDS | GRUENENTHAL GMBH (DE) | 2009-08-05 | — | — | EP | disclosed |
| US-20090042945-A1 | Benzo[d]isoxazol-3-yl-amine Compounds and Their Use as Vanilloid Receptor Ligands | GRUENENTHAL GMBH (DE) | 2009-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042945-A1 | Benzo[d]isoxazol-3-yl-amine Compounds and Their Use as Vanilloid Receptor Ligands | TRPV1, TRPV3, TRPV5 | PDE5A 1767/4885KMT2A 2664/4885ALDH1A1 1855/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.